We experimentally demonstrate a novel quasi-bound state in the continuum (BIC) resonance in the mid-infrared wavelength region with the resonant electric field confined as a slot mode within a low-refractive-index medium sandwiched between high-index layers. The structures studied here comprise coupled amorphous germanium guided-mode resonance (GMR) structures with a top one-dimensional grating layer and bottom uniform layer separated by a low-index silicon nitride layer. The slot-mode profile within the silicon nitride layer with mode field confinement >30% is achieved as a solution to the electromagnetic wave propagation through the coupled GMR structure with the dominant field component being perpendicular to the layers. The quasi-BIC resonance in symmetric 1D grating structures can be observed even at normal incidence when considering a realistic excitation beam with finite angular spread. The measured transmission peak is found to redshift (remain almost unchanged) under classical (full-conical) mounting conditions. The highest quality factor of ∼400 is experimentally extracted at normal incidence under a classical mounting condition with a resonance peak at 3.41 μm wavelength. Such slot-mode GMR structures with appropriately chosen low-index intermediate layers can find applications in resonantly enhanced sensing and active photonic devices.