Shunwu Xu, Jiajia He, Gangqin Xi, Lianhuang Li, Xiahui Han, Liqin Zheng, Jianxin Chen. Application Progress of Multiphoton Microscopy in Prognostic Prediction of Breast Tumor Microenvironments[J]. Laser & Optoelectronics Progress, 2022, 59(6): 0617013
- Laser & Optoelectronics Progress
- Vol. 59, Issue 6, 0617013 (2022)
Fig. 1. Energy level diagrams of nonlinear optical effect. (a) Two-photon excitation; (b) second harmonic generation
Fig. 2. Schematic diagram of breast tumor progression and tumor microenvironment changes. (a) Normal breast tissue and surrounding microenvironment; (b) breast tumor progression process; (c) surrounding microenvironment of invasive breast tumor
Fig. 3. Multiphoton microscopy images of main components in tumor microenvironment
Fig. 4. Schematic diagrams of 8 relative spatial distribution patterns of tumor cells and extracellular matrix collagen fibers and corresponding MPM images, scale is 500 µm[20]. (a) Relative spatial distribution pattern; (b) MPM images
Fig. 5. Schematic of extracting TACS corresponding microscopy features (TCMF)[30]. (a) Interception of a region of interest; (b) extraction of four types of TCMF
Fig. 6. Relative spatial distribution patterns of three important components of tumor microenvironment: tumor cells, lymphocytes and extracellular matrix collagen fibers and corresponding MPM images, scale is 500 µm[34]. (a) Relative spatial distribution pattern; (b) MPM images
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