Advances on SERS Based on Shifting of Raman Characteristic Peaks

Jianming Yang; Guojun Weng; Jianjun Li; Jian Zhu; Junwu Zhao

doi:10.3788/LOP202259.0617015

Journals >Laser & Optoelectronics Progress >Volume 59 >Issue 6 >Page 0617015 > Article

Laser & Optoelectronics Progress
Vol. 59, Issue 6, 0617015 (2022)

Advances on SERS Based on Shifting of Raman Characteristic Peaks

Jianming Yang¹, Guojun Weng^1、**, Jianjun Li^1、2, Jian Zhu¹, and Junwu Zhao^1、*

Author Affiliations

¹Key Laboratory of Biomedical Information Engineering, Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an , Shaanxi 710049, China

²Research Institute of Xi'an Jiaotong University, Hangzhou , Zhejiang 311200, China

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DOI: 10.3788/LOP202259.0617015 Cite this Article Set citation alerts

Jianming Yang, Guojun Weng, Jianjun Li, Jian Zhu, Junwu Zhao. Advances on SERS Based on Shifting of Raman Characteristic Peaks[J]. Laser & Optoelectronics Progress, 2022, 59(6): 0617015 Copy Citation Text

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Mechanism of shifting of Raman characteristic peaks. (a) Mechanical deformation of Raman reporter[17]; (b) charge transfer between molecules[15]

Fig. 1. Mechanism of shifting of Raman characteristic peaks. (a) Mechanical deformation of Raman reporter^[17]; (b) charge transfer between molecules^[15]

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Applications based on the shifting of Raman characteristic peaks. (a) Highly sensitive detection of liver cancer marker AFP[13]; (b) detection of ctDNA[34]

Fig. 2. Applications based on the shifting of Raman characteristic peaks. (a) Highly sensitive detection of liver cancer marker AFP^[13]; (b) detection of ctDNA^[34]

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Category	Target	Raman reporter	Mechanism	Content range	Limit of detection	Reference
Protein	Influenza-H1（H1）antigen	4-ATP	MD		2.2 nmol/L	［12］
	H1	4-ATP	MD		10 pmol/L	［29］
	c-Jun	Thiophenol	MD	1×10^-9-5×10^-6 mol/L	5 nmol/L	［17］
	Protein carbonylation	4-MBA	CT	0.18-9 nmol/mL		［30］
	P53-protein	6-mercaptopurine	MD		2.5 nmol/L	［12］
	AFP	4-MBA	MD	0.5-1000 ng/mL	0.5 ng/mL	［13］
	AFP	4-MBA	MD	10^-12-10^-8 mol/L	10^-12 mol/L	［31］
	AFP	DSNB	MD	10^-13-10^-10 mol/L		［16］
	GPC3	4-MBA	MD	10^-13-10^-10 mol/L		［16］
	PSA	Graphene	MD	0.05-25 ng/mL	0.01 ng/mL	［32］
Nucleic acid	miR-223	DSNB	MD	10^-17-10^-13 mol/L	10^-17 mol/L	［31］
	miR-223	DSNB	MD		10^-15 mol/L	［33］
	miR-26a-5p	4-MBA	MD		10^-15 mol/L	［33］
	miR-27a-3p	6-thio-guanine	MD		10^-15 mol/L	［33］
	ctDNA	DSNB	MD	10^-8-10^-16 mol/L	1.2×10^-16 mol/L	［34］
VOCs	Acetone	2，6-DMPI	CT			［35-36］
	Butylamine	2，6-DMPI	CT			［37］
	Ammonia	2，6-DMPI	CT			［28，35-36］
	CCl₄	2，6-DMPI	CT			［28，36］
	Farnesol	2，6-DMPI	CT		76×10^-6	［28］
	（+）-α-pinene	2，6-DMPI	CT			［28］
Metal ions	Mn²⁺，Ni²⁺，Fe²⁺，Cr³⁺，Fe³⁺	2，6-DMPI	CT		1 fmol/L	［28］
	Hg²⁺	DASS	MD	10^-3-10^-6 mol L^-1	10^-8 mol/L	［14］
	Fe³⁺	4-MBN	CT		0.1 pmol/L（free states） 0.08 μmol/L（protein-bound states）	［38］
Small molecules	Melamine	TNB	CT		10^-12 mol/L	［24］
Small molecules	Glucose	4-MBA	CT	10^-1-10^-6 mol L^-1	10^-6 mol L^-1	［26］

Table 1. Advances on SERS based on the shifting of Raman characteristic peaks

Jianming Yang, Guojun Weng, Jianjun Li, Jian Zhu, Junwu Zhao. Advances on SERS Based on Shifting of Raman Characteristic Peaks[J]. Laser & Optoelectronics Progress, 2022, 59(6): 0617015

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