Entanglement has been recognized as being crucial when implementing various quantum information tasks. Nevertheless, quantifying entanglement for an unknown quantum state requires nonphysical operations or post-processing measurement data. For example, evaluation methods via quantum state tomography require vast amounts of measurement data and likely estimation. Although a direct entanglement determination has been reported for the unknown pure state, it is still tricky for the mixed state. In this work, assisted by weak measurement and deep learning technology, we directly detect the entanglement (namely, the concurrence) of a class of two-photon polarization-entangled mixed states both theoretically and experimentally according to the local photon spatial distributions after weak measurement. In this way, the number of projective bases is much smaller than that required in quantum state tomography.