• Photonics Research
  • Vol. 9, Issue 2, 202 (2021)
Huanhao Li1、2、†, Chi Man Woo1、2、†, Tianting Zhong1、2, Zhipeng Yu1、2, Yunqi Luo3, Yuanjin Zheng3, Xin Yang4, Hui Hui4、5、*, and Puxiang Lai1、2、6、*
Author Affiliations
  • 1Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China
  • 2The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China
  • 3School of Electrical and Electronics Engineering, Nanyang Technological University, Singapore, Singapore
  • 4CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China
  • 5e-mail: hui.hui@ia.ac.cn
  • 6e-mail: puxiang.lai@polyu.edu.hk
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    DOI: 10.1364/PRJ.412884 Cite this Article Set citation alerts
    Huanhao Li, Chi Man Woo, Tianting Zhong, Zhipeng Yu, Yunqi Luo, Yuanjin Zheng, Xin Yang, Hui Hui, Puxiang Lai. Adaptive optical focusing through perturbed scattering media with a dynamic mutation algorithm[J]. Photonics Research, 2021, 9(2): 202 Copy Citation Text show less

    Abstract

    Optical imaging through or inside scattering media, such as multimode fiber and biological tissues, has a significant impact in biomedicine yet is considered challenging due to the strong scattering nature of light. In the past decade, promising progress has been made in the field, largely benefiting from the invention of iterative optical wavefront shaping, with which deep-tissue high-resolution optical focusing and hence imaging becomes possible. Most of the reported iterative algorithms can overcome small perturbations on the noise level but fail to effectively adapt beyond the noise level, e.g., sudden strong perturbations. Reoptimizations are usually needed for significant decorrelation to the medium since these algorithms heavily rely on the optimization performance in the previous iterations. Such ineffectiveness is probably due to the absence of a metric that can gauge the deviation of the instant wavefront from the optimum compensation based on the concurrently measured optical focusing. In this study, a square rule of binary-amplitude modulation, directly relating the measured focusing performance with the error in the optimized wavefront, is theoretically proved and experimentally validated. With this simple rule, it is feasible to quantify how many pixels on the spatial light modulator incorrectly modulate the wavefront for the instant status of the medium or the whole system. As an example of application, we propose a novel algorithm, the dynamic mutation algorithm, which has high adaptability against perturbations by probing how far the optimization has gone toward the theoretically optimal performance. The diminished focus of scattered light can be effectively recovered when perturbations to the medium cause a significant drop in the focusing performance, which no existing algorithms can achieve due to their inherent strong dependence on previous optimizations. With further improvement, the square rule and the new algorithm may boost or inspire many applications, such as high-resolution optical imaging and stimulation, in instable or dynamic scattering environments.
    Uf,1=TEop,1=[t11t1Ntm1tmntmNtM1tMN][e1eneN]=[upeakubg,mubg,M],

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    |upeak|2=|i=1Nt1iei|2=|p=1Nrt1pep+q=rN+1Nt1qeq|2=|rNt1pep+(1r)t1qeq|2,

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    Nt1pep=Nt1qeq=NR+NjI=N0+Rf(R)dR+Nj+If(I)dI=N0+R2πσ2eR22σ2dR+Nj+I2πσ2eI22σ2dI=N×σ2π+Nj×0=Nσ2π,

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    Ipeak=|upeak|2=|rNσ2π+(1r)Nσ2π|2=N2σ22π.

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    t1pep=R+jI=0Rf(R)dR+j+If(I)dI=σ2π.

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    Ipeak=|upeak,r|2=|rNσ2π+(1r)Nσ2π|2=(12r)2N2σ22π.

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    Ibg=|ubg|2=Var(ubg)=N2Var(tmi)=N22σ2=Nσ2.

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    η=ηrη0=Ipeak,r/IbgIpeak/Ibg=(12r)2N/2πN/2π=(12r)2,

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    r=(1η)/2.

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    r=(1ηex/η0)/2=(12πηex/N)/2.

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    μ(s)=r(s)/C,

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    Huanhao Li, Chi Man Woo, Tianting Zhong, Zhipeng Yu, Yunqi Luo, Yuanjin Zheng, Xin Yang, Hui Hui, Puxiang Lai. Adaptive optical focusing through perturbed scattering media with a dynamic mutation algorithm[J]. Photonics Research, 2021, 9(2): 202
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