To improve the tribological properties of TC4 surfaces, a TC4+Ni60+Ni-MoS₂ multi-component composite self-lubricating wear-resistant coating was prepared on the TC4 surface by the TruDisk4002 coaxial powder feeding fiber laser. The microstructure and the tribological performance of this coating were also analyzed. The results show that there are no cracks but a few pores within the coating. The main precipitation phases of the coating are TiC, Ti₂Ni, Ti₂SC, and α-Ti, and they are uniformly and compactly distributed within the coating. Ti₂SC and Ti₂Ni form the Ti₂SC-Ti₂Ni mosaic structure composite phase, and the misfit between (01 1ˉ0 )Ti2SC and (001 )Ti2Ni is 3.18%. Ti₂SC and Ti₂Ni form the coherent interface relationship. The coating micro-hardness is obviously higher than that of the substrate. The Ti₂SC-Ti₂Ni mosaic composite phase can effectively improve the anti-friction and wear resistance of coatings, and the wear mechanism of coatings is abrasive wear.