• Laser & Optoelectronics Progress
  • Vol. 59, Issue 12, 1200001 (2022)
Shuqi Mu1、2, Dashan Dong1、2, and Kebin Shi1、2、*
Author Affiliations
  • 1State Key Laboratory of Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China
  • 2Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, Shanxi , China
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    DOI: 10.3788/LOP202259.1200001 Cite this Article Set citation alerts
    Shuqi Mu, Dashan Dong, Kebin Shi. Label-Free Optical Imaging Technology[J]. Laser & Optoelectronics Progress, 2022, 59(12): 1200001 Copy Citation Text show less

    Abstract

    Label-free optical imaging technology can perform long-term, noninvasive, high-resolution imaging on living cells owing to its noninvasive characteristics. This technology has promising applications in biomedical research and clinical diagnosis. Label-free imaging technologies can be categorized into specific imaging and nonspecific imaging. In this paper, we review the commonly used label-free imaging. Herein, the imaging principles, advantages and disadvantages, as well as the recent progresses of unmarked imaging are introduced in detail. Furthermore, the future development of the label-free imaging technology is prospected.
    I1expiφ1=-1Okx-kxi,kx-kyjPkx,ky
    Okx,ky=I1mexpiφ1Pkx,ky+I1expiφ11-Pkx,ky
    Ox,y=-1Okx,kx
    fr=km24πnrnm2-1,
    2+km2usr=-4πfrur,
    ur=u0r+usr
    ur=u0rexpφRr
    FKx,Ky,Kz=kz2πiΦz=z0kx-k0x,ky-k0y×expik0z-kzz0
    Shuqi Mu, Dashan Dong, Kebin Shi. Label-Free Optical Imaging Technology[J]. Laser & Optoelectronics Progress, 2022, 59(12): 1200001
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