Author Affiliations
1Key Laboratory of Laser Life Sciences, Ministry of Education, South China Normal University, Guangzhou , Guangdong 510631, China2Guangdong Provincial Key Laboratory of Laser Life Sciences, Guangzhou , Guangdong 510631, China3Guangzhou Key Laboratory of Spectral Analysis and Functional Probe, Guangzhou , Guangdong 510631, China4College of Biophotonics, South China Normal University, Guangzhou , Guangdong 510631, Chinashow less
Fig. 1. Magnetron mode microwave source.(a) Schematic of the magnetron modulation mode; (b) typical magnetron modulation mode microwave generator
[78]; (c) top view and side view of the miniaturized microwave generator
[115]; (d) schematic of a small MTAI system
115] Fig. 2. High voltage discharge mode microwave source.(a) Schematic of high voltage discharge mode; (b) schematic of USMP experimental device
[74] Fig. 3. Continuous modulation mode microwave source.(a) Schematic of continuous modulation mode; (b) schematic of experimental apparatus for observing TA effect and TAR effect induced by monopulse and multi-pulse microwave sources
[90] Fig. 4. Experimental diagram of unit ring scanning endoscopy imaging system and resolution
[118] Fig. 5. Structure diagram and physical diagram of ring array acquisition system
[77] Fig. 6. Multivariate data acquisition system. (a) MTAI system composed of concave array detectors; (b) flexible array detector
[121] Fig. 7. FP thermoacoustic detector. (a) Structure of FP thermoacoustic detector
[122]; (b) lateral resolution of FP thermoacoustic detector
[123]; (c) axial resolution of FP thermoacoustic detector
[123] Fig. 8. Image reconstruction process of thermoacoustic imaging
Fig. 9. Schematic of different imaging algorithms. (a) Schematic of BP algorithm; (b) schematic of HDCS-MTAI algorithm
[124]; (c) schematic of 3D CS-MTAI algorithm
[125] Fig. 10. MTAI of mammary gland. (a) Schematic of a breast thermoacoustic scanner
[26]; (b) thermoacoustic imaging of a series of coronal and sagittal sections of the female breast, arrows show a large lobulated enhanced mass
[26]; (c) thermoacoustic imaging of the left breast and right breast of human
[26]; (d)
in vitro thermoacoustic imaging of tumor-bearing ewe breast
[121] Fig. 11. MTAI technique for brain imaging of rats
in vivo[129]. (a) Thermoacoustic imaging system of rat brain structure; (b) thermoacoustic imaging results of rat brain structure
Fig. 12. MTAI technique for cerebral hemorrhage imaging
[130]. (a) MTAI imaging system for GMH in mice; (b)-(e) thermoacoustic imaging of GMH in mice; (f)-(i) histological sections of mouse brain; (k)-(n) MTAI images after injection of 5 μL blood into the left ventricle; (j) indication of the location of blood injection; (o) histological images of Fig.12 (j); (p) TA signal curve along the dotted line shown in Fig.12 (l)
Fig. 13. MTAI system and microwave illumination methods
[131]. (a) Schematic of the MTAI system; (b) pyramidal horn antenna; (c) parallel in-phase microwave illumination; (d) parallel anti-phase microwave illumination
Fig. 14. Thermoacoustic imaging of finger arthritis
[116-117] Fig. 15. Schematic of different thermoacoustic probes. (a) Schematic of anti-Gall-Fe
3O
4 nanoparticles to enhance MTAI in nude mouse model with pancreatic cancer
[132]; (b) schematic of TA signal generation mechanism in BSA-GO nanoparticles
[141]; (c) schematic of TA signal and shock wave generation mechanism in defect-rich TiN NPs
[142]; (d) UHF-RF-acoustic contrast preparation and
in vitro imaging
[143] Research group | Main frequency | Pulsed width | Producing mode | Peak power |
---|
D. Xing | 434 MHz[74-77] 1.2 GHz[66-68] 3 GHz 6 GHz[69-73] | 10 ns 0.5 μs 0.5 μs 0.5 μs | HD MM MM MM | 4-40 MW 300 kW 70 kW 350 kW | H. Jiang | 1.2 GHz 3 GHz[50-52] | 0.5 μs 0.75 μs | MM MM | 300 kW 350 kW | L. V. Wang | 3 GHz 9 GHz 9.4 GHz | 0.5 μs 0.5 μs 0.6-2.2 μs | MM MM MM | 2 kW 25/10 kW 10 kW | R. A. Kruger | 434 MHz | 0.5 μs/1 ms | HD | 25 kW | V. Ntziachristos | ~100 MHz | 10 ns | HD | ~70 MW | H. Xin | 2.7-3.1 GHz[55] 3/1.4/2.5 GHz[56-60] | 400 ns 0.5-1.5 μs | MC MM | 5.2 kW 4/10 kW | S. K. Patch | 108 MHz[44-45] | 700 ns | MM | 20 kW | A. Arbabian | 2/2.1 GHz[61-72] | NA | MC | 120 W | Y. Zheng X. Wang | 2.7/2.9/3.1 GHz[63-65] 915 MHz/2.45 GHz | NA 0.1-10 μs | MC MC | NA 20 kW |
|
Table 1. Microwave source types studied by each group
Research groupe | Type | Shape | Array element | Center frequency | Resolution |
---|
D. Xing | Single-element[68-71] Multi-element[83] Multi-element[77] Multi-element[80] | NA Linear Full ring Flexibility | 1 128/64 384/256 64 | 2.5/3.5 MHz 2.5/2 MHz 2.5/5 MHz 7.5 MHz | 0.5 mm 2.2 mm NA NA | H. Jiang | Single-element[50-52] Multi-element | NA Linear | 1 128 | 2.25 MHz | 500 μm | L. V. Wang | Single-element Multi-element | NA Linear | 1 30 | 1/3.5 MHz 2.25 MHz | 1.5 mm 1.9-2.5 mm | R. A. Kruger | Multi-element | NA | 64 | 1 MHz | ~1 mm | V. Ntziachristos | Single-element | NA | 1 | 7.5 MHz | 170 μm | H. Xin | Single-element[55] Multi-element[56-60] | NA Linear | 1 128 | 1 MHz 2.25 MHz | 500 μm mm order | S. K. Patch | Single-element[44] Multi-element[45-46] | NA NA | 1 96 | 2.25 MHz 1-4 MHz | NA 250 μm | A. Arbabian | Single-element[61-62] | NA | NA | 0.5 MHz | NA | Y. Zheng | Single-element[63-65] | NA | 1 | NA | NA |
|
Table 2. Thermoacoustic sensor types studied by each group