Highly effective and adaptable fabrication of high-quality micro-hole arrays for safety filters remains challenging. Therefore， in this study， a combination of laser and electrochemical machining technology was developed for preparing micro-hole arrays for safety filters. An experimental processing system for laser–electrochemical combined machining was devised， the effects of process parameters on the processing quality were investigated， and a safety filter sample was prepared. The results indicated that in the laser processing， the laser cutting path significantly affects the outer shape of the through-hole， and the outer roundness of the through-hole can be significantly improved using the optimized concentric circle path （outer diameter： 270 μm， inner diameter： 230 μm， and spacing distance： 5 μm）. A higher laser power and lower cutting speed correspond to a larger through-hole diameter and heat-affected zone. NaNO3-ethylene glycol solution as polishing electrolyte can form a diffusion layer on the machining surface for electrolytic polishing and remove the spatters and burrs generated by laser processing. Using the optimized process parameters， 253 micro-hole structures with a diameter of 0.31 mm were machined， and the variance of the inlet and outlet diameters was only 2.02 and 1.71， respectively， indicating a high dimensional consistency. The laser-electrochemical combined process has considerable potential for the fabrication of high-quality micro-hole arrays on thin-walled workpieces.