• Acta Optica Sinica
  • Vol. 39, Issue 10, 1017001 (2019)
Ziye Fang and Jingjing Yu*
Author Affiliations
  • School of Physics and Information Technology, Shaanxi Normal University, Xi′an, Shaanxi 710119, China
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    DOI: 10.3788/AOS201939.1017001 Cite this Article Set citation alerts
    Ziye Fang, Jingjing Yu. Simulation of Bioluminescence Tomography Based on Improved Half Threshold Algorithm[J]. Acta Optica Sinica, 2019, 39(10): 1017001 Copy Citation Text show less
    Simulation experiment with single-source. (a) Digital mouse model containing source; (b) surface intensity distribution obtained by forward simulation
    Fig. 1. Simulation experiment with single-source. (a) Digital mouse model containing source; (b) surface intensity distribution obtained by forward simulation
    Cross-sectional views of reconstruction results on the XY plane at Z=9.2 mm center of the real light source obtained by three algorithms in single-source case. (a) PHTPA; (b) HTA ; (c) IRW-L1/2. Black circle represents real light source
    Fig. 2. Cross-sectional views of reconstruction results on the XY plane at Z=9.2 mm center of the real light source obtained by three algorithms in single-source case. (a) PHTPA; (b) HTA ; (c) IRW-L1/2. Black circle represents real light source
    Simulation experiments with double-light source. (a) Digital mouse model containing source; (b) surface intensity distribution when the density ratio is 1∶1; (c) surface intensity distribution when density ratio is 1∶2
    Fig. 3. Simulation experiments with double-light source. (a) Digital mouse model containing source; (b) surface intensity distribution when the density ratio is 1∶1; (c) surface intensity distribution when density ratio is 1∶2
    Cross-sectional views of reconstruction results on the XY plane at Z=17.0 mm center of the real light source obtained by three algorithms in double-source case. (a)-(c) Reconstruction results of PHTPA, HTA, and IRW-L1/2 when the density ratio is 1∶1; (d)-(f) reconstruction results of PHTPA, HTA, and IRW-L1/2 when the density ratio is 1∶2. Black circle represents the real light source
    Fig. 4. Cross-sectional views of reconstruction results on the XY plane at Z=17.0 mm center of the real light source obtained by three algorithms in double-source case. (a)-(c) Reconstruction results of PHTPA, HTA, and IRW-L1/2 when the density ratio is 1∶1; (d)-(f) reconstruction results of PHTPA, HTA, and IRW-L1/2 when the density ratio is 1∶2. Black circle represents the real light source
    Comparison of convergence rates of PHTPA(k=40) and HTA(k=50)
    Fig. 5. Comparison of convergence rates of PHTPA(k=40) and HTA(k=50)
    ELE of PHTPA and HTA varying with sparse parameter k
    Fig. 6. ELE of PHTPA and HTA varying with sparse parameter k
    ParameterMuscleHeartStomachLiverKidneyLung
    μa /mm-10.100.210.010.1260.0660.22
    μs /mm-11.202.001.740.5632.2502.30
    Table 1. Optical parameters of digital mouse organs at 670 nm wavelength
    MethodReconstruction position center /mmELE /mm
    PHTPA(11.15,6.14,9.66)0.66
    HTA(11.15,6.17,9.75)0.73
    IRW-L1/2(12.20,7.03,8.99)1.21
    Table 2. Reconstruction results in single-source case
    MethodTargetReconstruction position center /mmELE /mm
    PHTPAsource 1(11.60,7.73,18.51)1.58
    source 2(12.24, 11.75,16.33)0.75
    HTAsource 1(10.79,8.02,18.27)1.74
    source 2(12.21,11.76,16.31)0.75
    IRW-L1/2source 1(12.61,9.22,17.01)1.37
    source 2(12.14,10.74 ,16.37)1.40
    Table 3. Reconstruction results in the double-source case when density ratio is 1∶1
    MethodTargetReconstruction position center /mmELE /mm
    PHTPAsource 1(11.60,7.73,18.52)1.59
    source 2(12.24,11.75,16.33)0.75
    HTAsource 1(10.76,8.03,18.26)1.76
    source 2(12.21,11.76,16.31)0.75
    IRW-L1/2source 1(12.57,9.09,16.86)1.24
    source 2(12.14,10.06,16.15)1.60
    Table 4. Reconstruction results in the double-source case with density ratio of 1∶2
    Ziye Fang, Jingjing Yu. Simulation of Bioluminescence Tomography Based on Improved Half Threshold Algorithm[J]. Acta Optica Sinica, 2019, 39(10): 1017001
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