• Journal of Inorganic Materials
  • Vol. 36, Issue 10, 1074 (2021)
YANG Mai1、3, ZHU Min1, CHEN Yu2、*, and ZHU Yufang1、3、*
Author Affiliations
  • 11. School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
  • 22. School of Life Sciences, Shanghai University, Shanghai 200444, China
  • 33. Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
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    Phototherapy, a tumor therapeutic modality, has been widely studied due to its advantages of minimal invasiveness, low side effect, and high therapeutic efficacy. However, single phototherapy cannot achieve complete tumor elimination. Recently, the emerging two-dimensional nanomaterials have attracted great attention in the field of phototherapy. Here, FePS3 nanosheets were prepared, and then its phototherapeutic properties were investigated. The bulk FePS3 was synthesized by a high-temperature solid-phase method and FePS3 nanosheets were obtained by an ultrasonic-assisted liquid phase exfoliating method. The nanosheets displayed particle morphology with average hydrated size of less than 200 nm (153 nm in average), performed photothermal conversion efficiency of 19.7% under 1064 nm laser irradiation, and generated reactive oxygen species under 660 nm laser irradiation. Cell experiment results showed that FePS3 nanosheets had excellent photothermal and photodynamic therapeutic effects. Therefore, FePS3 nanosheets can be used as both photothermal agent and photosensitizer to achieve combined photothermal-photodynamic therapy for treating tumors, which shows great application potential.

    随着人们对光和光-物质相互作用的物理本质了解得越来越深入, “生物医学光学”逐渐成为一个新兴领域。光学治疗的快速发展催生了包括光热治疗、光动力学治疗策略在内的肿瘤治疗手段。其中光动力学治疗的三要素为光敏剂、一定波长的激光刺激和组织氧。光动力学治疗可利用光化学反应产生的单线态氧(1O2)等活性氧(Reactive oxygen species, ROS)杀死肿瘤细胞, 具有更小的侵入性、更低的副作用和更弱的耐药性等优势[1,2,3]。光热治疗则是利用光热剂(Photothermal agent)将光能转化为热能, 产生局部加热效果而消融血管化微环境较差的肿瘤。光学治疗可以通过改变辐照部位、持续时间和激光功率密度而精确控制治疗组织范围、时间和功效, 实现辐照区域可控, 确保更低的副作用和更好的能量聚集, 从而产生显著的疗效。但是, 单一模式的光学治疗不能完全消除顽固性肿瘤, 仍有肿瘤复发或转移的风险。因此, 有必要探索设计包含至少一种光学治疗方法的联合治疗策略。

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    Mai YANG, Min ZHU, Yu CHEN, Yufang ZHU. FePS3 Nanosheets: Preparation and Potential in Photothermal-photodynamic Therapy [J]. Journal of Inorganic Materials, 2021, 36(10): 1074
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    Received: Dec. 31, 2020
    Accepted: --
    Published Online: Nov. 26, 2021
    The Author Email: CHEN Yu (chenyuedu@shu.edu.cn), ZHU Yufang (zjf2412@163.com)