• Acta Optica Sinica
  • Vol. 39, Issue 6, 0617001 (2019)
Di Lu1、2, Xiao Wei1、2, Xin Cao1、2、**, Xiaowei He1、2、*, and Yuqing Hou1、2
Author Affiliations
  • 1 School of Information Sciences & Technology, Northwest University, Xi'an, Shaanxi 710127, China;
  • 2 Key Laboratory for Radiomics and Intelligent Sense of Xi'an, Northwest University, Xi'an, Shaanxi 710127, China
  • show less
    DOI: 10.3788/AOS201939.0617001 Cite this Article Set citation alerts
    Di Lu, Xiao Wei, Xin Cao, Xiaowei He, Yuqing Hou. Fast Reconstruction Method for Fluorescence Molecular Tomography Based on Autoencoder[J]. Acta Optica Sinica, 2019, 39(6): 0617001 Copy Citation Text show less
    Framework of FMT rapid reconstruction based on autoencoder
    Fig. 1. Framework of FMT rapid reconstruction based on autoencoder
    Diagram of the non-homogeneous cylinder phantom. (a) Model of non-homogeneous cylinder phantom; (b) distribution of shot points at plane of z=15 mm
    Fig. 2. Diagram of the non-homogeneous cylinder phantom. (a) Model of non-homogeneous cylinder phantom; (b) distribution of shot points at plane of z=15 mm
    Result diagram of single-source reconstruction. (a)-(c) Stereogram of reconstruction results, the 2D cross-section views at planes of x=0 mm and z=15 mm with original data; (d)-(f) stereogram of reconstruction results, the 2D cross-section views at planes of x=0 mm and z=15 mm with AE method
    Fig. 3. Result diagram of single-source reconstruction. (a)-(c) Stereogram of reconstruction results, the 2D cross-section views at planes of x=0 mm and z=15 mm with original data; (d)-(f) stereogram of reconstruction results, the 2D cross-section views at planes of x=0 mm and z=15 mm with AE method
    T1 and T2 reconstruction results using AE method under different dimensionality. (a) Reconstruction results of T1; (b) reconstruction results of T2
    Fig. 4. T1 and T2 reconstruction results using AE method under different dimensionality. (a) Reconstruction results of T1; (b) reconstruction results of T2
    Result diagram of double-sources reconstruction. (a)-(c) Stereogram of reconstruction results, the 2D cross-section views at planes of x=0 mm and z=15 mm with original data; (d)-(f) stereogram of reconstruction results, the 2D cross-section views at planes of x=0 mm and z=15 mm with AE method
    Fig. 5. Result diagram of double-sources reconstruction. (a)-(c) Stereogram of reconstruction results, the 2D cross-section views at planes of x=0 mm and z=15 mm with original data; (d)-(f) stereogram of reconstruction results, the 2D cross-section views at planes of x=0 mm and z=15 mm with AE method
    Single source reconstruction results in digital mouse experiments using AE method under different dimensionality
    Fig. 6. Single source reconstruction results in digital mouse experiments using AE method under different dimensionality
    Results of single source in digital mouse experiments. (a)-(c) Stereogram of reconstruction results, the 2D cross-section views at planes of x=11.9 mm and z=16.4 mm with original data; (d)-(f) stereogram of reconstruction results, the 2D cross-section views at planes of x=11.9 mm and z=16.4 mm with AE method
    Fig. 7. Results of single source in digital mouse experiments. (a)-(c) Stereogram of reconstruction results, the 2D cross-section views at planes of x=11.9 mm and z=16.4 mm with original data; (d)-(f) stereogram of reconstruction results, the 2D cross-section views at planes of x=11.9 mm and z=16.4 mm with AE method
    Reconstruction results of T1 and T2 when compressed to different dimensions using AE. (a) Reconstruction results of T1; (b) reconstruction results of T2
    Fig. 8. Reconstruction results of T1 and T2 when compressed to different dimensions using AE. (a) Reconstruction results of T1; (b) reconstruction results of T2
    Results of double-sources in digital mouse experiments. (a)-(c) Stereogram of reconstruction results, the 2D cross-section views at planes of x=11.9 mm and z=16.4 mm with original data; (d)-(f) stereogram of reconstruction results, the 2D cross-section views at planes of x=11.9 mm and z=16.4 mm with AE method
    Fig. 9. Results of double-sources in digital mouse experiments. (a)-(c) Stereogram of reconstruction results, the 2D cross-section views at planes of x=11.9 mm and z=16.4 mm with original data; (d)-(f) stereogram of reconstruction results, the 2D cross-section views at planes of x=11.9 mm and z=16.4 mm with AE method
    Organμax/mm-1μsx/mm-1μam/mm-1μsm/mm-1
    Muscle0.005210.800.006810.30
    Heart0.00836.730.01046.60
    Lungs0.013319.700.020319.50
    Liver0.03297.000.01766.60
    Bone0.006060.090.003030.74
    Table 1. Optical parameters for non-homogeneous cylinder phantom
    Method (dimensionality)LE /mmWCLE /mmNRMSE /mm-1Time /sDice
    IVTCG0.730.25463.36407.680.5200
    AE+IVTCG(50)0.730.24380.02394.220.6667
    AE+IVTCG(100)0.730.17890.01863.980.6667
    AE+IVTCG(150)0.790.26210.02044.370.6000
    AE+IVTCG(200)0.790.41000.02804.480.5200
    AE+IVTCG(300)1.260.60470.03184.760.4444
    Table 2. Reconstruction results of single source non-homogeneous cylinder phantom simulation experiments using AE method
    Number of excitation sourceLE /mmWCLE /mmNRMSE /mm-1Time /sDice
    360.730.17890.01863.980.6667
    180.730.20940.03344.210.6667
    90.730.52350.02364.850.6667
    61.170.41180.04744.020.4700
    31.261.26000.05344.170.4000
    Table 3. Quantitative simulation results of single source non-homogeneous cylinder using AE method under different number of excitation sources
    Noise level /%LE /mmWCLE /mmNRMSE /mm-1Time /sDice
    50.730.67230.01524.090.6667
    100.730.68790.01594.200.6667
    150.730.14610.01924.330.6667
    200.790.20330.01794.010.6000
    251.260.72130.01644.800.4000
    Table 4. Quantitative simulation results of single source non-homogeneous cylinder using AE method under different noise levels
    MethodTargetLE /mmWCLE /mmNRMSE /mm-1Time /sDice
    IVTCGT10.61690.49150.329124.34380.2361
    T21.39710.9369
    AE+IVTCGT10.61690.48260.049110.51700.4444
    T21.32860.4598
    Table 5. Quantitative simulation results of double sources non-homogeneous cylinder phantom simulation experiments using AE method
    MethodLE /mmWCLE /mmNRMSE /mm-1Time /sDice
    IVTCG0.404250.42680.25095.81120.4000
    AE+IVTCG0.404250.56350.03431.73080.5700
    Table 6. Quantitative simulation results of single source in digital mouse experiments using AE method
    MethodTargetLE /mmWCLE /mmNRMSE /mm-1Time /sDice
    IVTCGT10.61691.28760.261747.7760.3333
    T20.68330.9369
    AE+IVTCGT10.61691.28760.022020.1710.4000
    T20.51690.4579
    Table 7. Quantitative simulation results of double sources in digital mouse experiments using AE method
    Di Lu, Xiao Wei, Xin Cao, Xiaowei He, Yuqing Hou. Fast Reconstruction Method for Fluorescence Molecular Tomography Based on Autoencoder[J]. Acta Optica Sinica, 2019, 39(6): 0617001
    Download Citation