A composite method combining the laser cladding and plasma spraying is adopted to prepare the fluorinated bio-ceramic composite hydroxyapatite (HA) coating. The mixed powder of HA, calcium fluoride (CaF2) and titanium (Ti) is laser cladded on the Ti-6Al-4V substrates to produce the transition layer, on which HA·CaF2 powder is plasma sprayed as Ca10 (PO4) 6Fx (OH)2-x rich ceramic layer. The influence of F content on the phase composition, bonding strength, surface morphology and biological activity of the composite coating is studied by tensile test, simulated body fluid (SBF) immersion test and X-ray diffraction (XRD)、scanning electron microscope and energy dispersive spectrometer (SEM/EDS) analysis. It is shown that the bonding strength of the above composite coating increases up to 20.1 MPa and reaches its maximum value of 28.4 MPa when x=1.5, the crystallinity and the biological activity of the coating as well as the number of the cracks in the coating surface increases with x, the coating with optimal comprehensive performance is obtained when x=1.0~1.5.