Distributed optical fiber sensing based on Brillouin optical time-domain analysis (BOTDA) allows the simultaneous measurement of parameters such as temperature and strain. In addition, it provides an ultralong sensing distance, high spatial resolution, and high precision, and is widely used in structural health monitoring in areas such as infrastructure and aerospace engineering. However, the BOTDA sensing system exhibits cross-sensitivity between temperature and strain, hindering the discrimination of the influencing factors during measurement and severely restricting the sensing and monitoring capabilities. To address these problems, this article introduces, analyzes, and compares seven methods based on reference fiber, grating assistance, multiparameter assistance, special fiber, dual-wavelength sensing, Raman/Rayleigh scattering assistance, and neural networks to provide a reference for research and application of cross-sensitivity in optical fiber sensing.