Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood–brain barrier by sound

O. Semyachkina-Glushkovskaya; A. Abdurashitov; A. Pavlov; A. Shirokov; N. Navolokin; O. Pavlova; A. Gekalyuk; M. Ulanova; N. Shushunova; A. Bodrova; E. Saranceva; A. Khorovodov; I. Agranovich; V. Fedorova; M. Sagatova; A. E. Shareef; C. Zhang; D. Zhu; V. Tuchin

doi:10.3788/COL201715.090002

Journals >Chinese Optics Letters >Volume 15 >Issue 9 >Page 090002 > Article

Chinese Optics Letters
Vol. 15, Issue 9, 090002 (2017)

Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood–brain barrier by sound

O. Semyachkina-Glushkovskaya¹, A. Abdurashitov¹, A. Pavlov^1、2、*, A. Shirokov³, N. Navolokin⁴, O. Pavlova¹, A. Gekalyuk¹, M. Ulanova¹, N. Shushunova¹, A. Bodrova¹, E. Saranceva¹, A. Khorovodov¹, I. Agranovich¹, V. Fedorova¹, M. Sagatova¹, A. E. Shareef¹, C. Zhang^5、6, D. Zhu^5、6, and V. Tuchin^1、7、8

Author Affiliations

¹Saratov National Research State University, Saratov 410012, Russia

²Yuri Gagarin State Technical University of Saratov, Saratov 410054, Russia

³Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov 410049, Russia

⁴Saratov State Medical University, Saratov 410012, Russia

⁵Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics (WNLO), Huazhong University of Science and Technology (HUST), Wuhan 430074, China

⁶Key Laboratory for Biomedical Photonics, HUST, Ministry of Education, Wuhan 430074, China

⁷National Research Tomsk State University, Tomsk 634050, Russia

⁸Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov 410028, Russia

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DOI: 10.3788/COL201715.090002 Cite this Article Set citation alerts

O. Semyachkina-Glushkovskaya, A. Abdurashitov, A. Pavlov, A. Shirokov, N. Navolokin, O. Pavlova, A. Gekalyuk, M. Ulanova, N. Shushunova, A. Bodrova, E. Saranceva, A. Khorovodov, I. Agranovich, V. Fedorova, M. Sagatova, A. E. Shareef, C. Zhang, D. Zhu, V. Tuchin. Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood–brain barrier by sound[J]. Chinese Optics Letters, 2017, 15(9): 090002 Copy Citation Text

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Abstract

The cerebral blood flow (CBF) alterations related to sound-induced opening of the blood–brain barrier (BBB) in adult mice are studied using laser speckle contrast imaging (LSCI) and wavelet analysis of vascular physiology. The results clearly show that the opening of the BBB is accompanied by the changes of venous but not microvessel circulation in the brain. The elevation of the BBB permeability is associated with the decrease of venous CBF and the increase of its complexity. These data suggest that the cerebral veins rather than microvessels are sensitive components of the CBF related to the opening BBB.