Ballistic and cruise missile are the major threat in high technology war, the most efficient defense for ballistic missile is the boost phase interception. First of all, the failure reason and the lessons learned of US air borne laser project are summarized.Then the concept, superiority, research project and current status, as well as the problems and the challenges of anti-missile UAV-borne laser weapon are reviewed and analyzed. Finally, the principle, characteristics and recent progress and technical challenges of the diode pumped alkali laser and fiber combining laser used in the boost phase interception are discussed and analyzed.