The accident occurrence of UAV is increasing relatively with the development of it, which become a fatal threat to national defence and social security. Handling such problem has become a difficult mission for all countries. Conventional arms, due to the restriction, are hard to defend UAV. With the development of technology, tactical laser weapon is revealing great advantage in defending such aerocraft. In this article, the development and actuality of tactical laser anti-UAV are sorted out. The key technology in three aspects, which are high energy laser source includes high energy laser and beam combining, quisition tracking pointing, high efficient destroying, are analyzed and summarized. This article points out the developing direction of tactical laser anti-UAV, which could be considered as a reference as well.