The anti-synchronization control problem of NH3 laser driven by multi-system is researched. Based on Lyapunov stability theory, through constructing Lyapunov function, the signal anti-synchronization is realized in which stimulated Raman scattering laser and Rossler system are taken as a driving system and NH3 laser system is taken as a response system. The correctness of anti-synchronization principle is verified by numerical simulation. Simulation results show that anti-synchronization is realized completely under the anti-synchronization controller. The controller has certain adaptability which can be used in any chaos systems.