Zehai Hou, Lianbo Guo, Weiliang Wang, Yanwu Chu, Furi Lin. Research Progress on Laser-Induced Breakdown Spectroscopy in Biomedicine[J]. Laser & Optoelectronics Progress, 2023, 60(24): 2400004
- Laser & Optoelectronics Progress
- Vol. 60, Issue 24, 2400004 (2023)
![Schematic diagram of the principle of LIBS technology[18]](/richHtml/lop/2023/60/24/2400004/img_01.jpg)
Fig. 1. Schematic diagram of the principle of LIBS technology[18]
![LIBS for blood cancer discrimination[41]. (a) Sample preparation steps; (b) classification accuracy of different methods; (c) confusion matrix of RSM-LDA](/richHtml/lop/2023/60/24/2400004/img_02.jpg)
Fig. 2. LIBS for blood cancer discrimination[41]. (a) Sample preparation steps; (b) classification accuracy of different methods; (c) confusion matrix of RSM-LDA
![LIBS detection of drug half-life[45]. (a) Schematic of sample preparation process; (b) schematic of LIBS system and spectral acquisition method; (c) spectra of samples and silicon substrate](/Images/icon/loading.gif){kind=icon}
Fig. 3. LIBS detection of drug half-life[45]. (a) Schematic of sample preparation process; (b) schematic of LIBS system and spectral acquisition method; (c) spectra of samples and silicon substrate
Fig. 4. Classification results of LIBS combined with SVM and KNN in infiltrating glioma[55]. (a) Experimental setup for LIBS; (b) LIBS spectra of glioma samples; (c) classification results of SVM and KNN
Fig. 5. Preprocessing of hair samples and analysis of experimental results[58]
Fig. 6. LIBS imaging technology. (a) Schematic diagram of the LIBS imaging principle[66]; (b) single-cell nanoscale LIBS imaging[64]
Fig. 7. LIBS-based skin tissue imaging[67]. (a) Elemental imaging of healthy skin tissue; (b) elemental imaging of different types of skin cancer
Fig. 8. Milestones of LIBS imaging in biomedical applications[66].(a) 3D imaging of the entire kidney; (b) slice imaging; (c) depth ablation imaging; (d) sample surface under SEM
Fig. 9. Diagrams of elemental imaging in deep ablated brain tissue block[73]. (a) Right brain; (b) left brain; (c) LIBS layer-by-layer analysis; (d) brain sample embedded in paraffin wax; (e) samples after LIBS ablation; (f) elemental imaging of right brain; (g) elemental imaging of left brain
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Table 1. Literature on the application of LIBS technology in the biomedical field in the past five years
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