In order to decrease the residual stress and distortion of laser repairing titanium alloy substrate, the influence of different laser scanning paths on the residual stress and distortion of repairing substrate was researched by using ANSYS parameter design language, the residual stress distribution of different layers and different scanning paths was simulated. The result shows that the residual stress of both ends of repairing substrate is higher than other location, the residual stress of repairing layers is higher in both ends, and lower in the middle. The residual stress and its ranges in different repairing layers is lower by using direction orthogonal changing scanning paths, and the flatness of repairing substrate decreases. The residual stress of repairing substrates under different scanning paths was measured by indentation test, the distortion curves of different scanning paths were drawn, which was in good agreement with simulated results.