Functional Nanomaterials for Electrochemical SRAS-CoV-2 Biosensors: a Review

Yao LIU; Xunhai YOU; Bing ZHAO; Xiaoying LUO; Xing CHEN

doi:10.15541/jim20220384

Journals >Journal of Inorganic Materials >Volume 38 >Issue 1 >Page 32 > Article

Journal of Inorganic Materials
Vol. 38, Issue 1, 32 (2023)

Functional Nanomaterials for Electrochemical SRAS-CoV-2 Biosensors: a Review

Yao LIU^1、2, Xunhai YOU^1、3, Bing ZHAO^1、3, Xiaoying LUO^4、*, and Xing CHEN^{1、2、3、*}

Author Affiliations

¹1. Institute of Industry and Equipment Technology, Hefei University of Technology, Hefei 230009, China

²2. School of Resources and Environmental Engineering, Hefei University of Technology, Hefei 230009, China

³3. School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009, China

⁴4. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200032, China

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DOI: 10.15541/jim20220384 Cite this Article

Yao LIU, Xunhai YOU, Bing ZHAO, Xiaoying LUO, Xing CHEN. Functional Nanomaterials for Electrochemical SRAS-CoV-2 Biosensors: a Review[J]. Journal of Inorganic Materials, 2023, 38(1): 32 Copy Citation Text

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1. Structure of SARS-CoV-2

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2. Electrochemical biosensors based on gold nanomaterials for the detection of SARS-CoV-2

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3. Metal oxide nanomaterials used in electrochemical sensors to detect SARS-CoV-2

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4. Electrochemical biosensors based on carbon nanomaterials for the detection of SARS-CoV-2

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5. Graphene nanocomposites used in electrochemical sensors to detect SARS-CoV-2

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6. Paper-based electrochemical biosensor for diagnosing COVID-19^[59]

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Detection method	Time/h	Advantage	Disadvantage
Reverse transcrition-polymerase chain reaction (RT-PCR)	4-6	High sensitivity and reliabilityLow costVersatility in sample types	Special instrumentsComplicated operationTime-consuming
Enzyme linked immunosorbent assay (ELISA)	1-3	Simple operationLow priceFast detection	Low specificitySuitability only for the late stage of the disease
Surface-enhancedRaman spectroscopy (SERS)	<1	Simple constructionGood repeatability	Specialized SERS active substrates
Electrochemical detection	<1	Lower costSimpler constructionHigher speciﬁcityRelatively lower sensitivity	Lower clinical trial accuracy

Table 1. Comparison of detection methods for SARS-CoV-2 detection

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Material	Method	Detecting object	Limit of detection	Ref.
AuNPs	i-t	RNA or cDNA	N/A	[46]
Gold nanoneedle	SWV	S geneOrf1ab gene	5.0×10^-18g·μL^-16.8×10^-18g·μL^-1	[47]
AuNPs/PEDOT	EIS	Positive and negative serum sample	N/A	[48]
Au@Fe₃O₄/rGO	DPV	RNA	3×10^-18mol·L^-1	[6]
Co-TiO₂ nanotubes	i-t	RBD	7×10^-10 mol·L^-1	[49]
ZnO/rGO	EIS	N protein antigens	2×10^-14g·mL^-1	[5]
Carbon black nanomaterial	LSV	S proteinN protein	1.9×10^-8g·mL^-18×10^-9g·mL^-1	[50]
Laser-engraved graphene	LSV	N-protein,S1-IgMS1-IgGC-reactive protein	N/A	[61]
AuNPs/rGO	EIS	S1 proteinRBD antibodies	2.8×10^-15 mol·L^-11.69×10^-14 mol·L^-1	[55]
SiO₂@UiO-66	EIS	S protein	1×10^-13g·mL^-1	[57]
GO	SWV	IgGIgM	9.6×10^-10g·mL^-11.4×10^-10g·mL^-1	[59]
Au@Pt/MIL-5(Al)	DPV	N-protein	8.33×10^-12g·mL^-1	[58]

Table 2. Comparison of SARS-CoV-2 detection performance of electrochemical sensors constructed from different nanomaterials

Yao LIU, Xunhai YOU, Bing ZHAO, Xiaoying LUO, Xing CHEN. Functional Nanomaterials for Electrochemical SRAS-CoV-2 Biosensors: a Review[J]. Journal of Inorganic Materials, 2023, 38(1): 32

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