Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma

Dong XU; Yufang ZHU; Yuanyi ZHENG; Yu LUO; Hangrong CHEN

doi:10.15541/jim20200016

Journals >Journal of Inorganic Materials >Volume 35 >Issue 11 >Page 1277 > Article

Journal of Inorganic Materials
Vol. 35, Issue 11, 1277 (2020)

Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma

Dong XU^1、2, Yufang ZHU^1、2, Yuanyi ZHENG³, Yu LUO^2、4、*, and Hangrong CHEN^2、*

Author Affiliations

¹School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

²Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

³Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China;

⁴School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China

show less

DOI: 10.15541/jim20200016 Cite this Article

Dong XU, Yufang ZHU, Yuanyi ZHENG, Yu LUO, Hangrong CHEN. Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma[J]. Journal of Inorganic Materials, 2020, 35(11): 1277 Copy Citation Text

show less

TEM images of superparamagnetic Fe3O4 nanoparticles (a), XRD patterns (b), XPS spectra (c), r2 relaxation rate (d),saturation magnetization (e), and temperature rise curves of different Fe concentrations in an alternating magnetic field (f)

1. TEM images of superparamagnetic Fe₃O₄ nanoparticles (a), XRD patterns (b), XPS spectra (c), r₂ relaxation rate (d),saturation magnetization (e), and temperature rise curves of different Fe concentrations in an alternating magnetic field (f)

Download full size | View in the Article

Digital photo of Fe3O4 dispersed in PLGA liquid to obtain a homogeneous fluid (a); Digital photo of PLGA / Fe3O4 fluid sucked with a 1 mL syringe (b); Digital photo of liquid-solid phase transition of PLGA / Fe3O4 fluid driven into water with a syringe (c)

2. Digital photo of Fe₃O₄ dispersed in PLGA liquid to obtain a homogeneous fluid (a); Digital photo of PLGA / Fe₃O₄ fluid sucked with a 1 mL syringe (b); Digital photo of liquid-solid phase transition of PLGA / Fe₃O₄ fluid driven into water with a syringe (c)

Download full size | View in the Article

3. SEM image of PLGA/Fe₃O₄ (PF) composite (a), with its corresponding EDX spectrum (b), and different elements mapping (c)

Download full size | View in the Article

4. Temperature rise of PLGA/Fe₃O₄composite (PF) in AMF (a), cytotoxicity (b) and in vitro T₂-weighted MR imaging (c), and the cytocompatibility of the inhibitor EGCG under simulated magnetocalormic temperature rise (43 ℃, d)

Download full size | View in the Article

5. Therapeutic effects of different groups on MG-63 cells under AMF

Download full size | View in the Article

Download Citation

Save the article for my favorites

Paper Information