• Chinese Journal of Lasers
  • Vol. 45, Issue 2, 207008 (2018)
Lan Shanyou1、2, Zhang Da1、3, Liu Xiaolong1、3, and Zeng Yongyi1、4、*
Author Affiliations
  • 1[in Chinese]
  • 2[in Chinese]
  • 3[in Chinese]
  • 4[in Chinese]
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    DOI: 10.3788/CJL201845.0207008 Cite this Article Set citation alerts
    Lan Shanyou, Zhang Da, Liu Xiaolong, Zeng Yongyi. Tumor-Microenvironment Activable Smart Nanocarrier System for Photodynamic Therapy of Cancers[J]. Chinese Journal of Lasers, 2018, 45(2): 207008 Copy Citation Text show less
    (a) Fabrication of photosensitive nanoparticles by amphiphilic dipeptide- or amino-acid- tuned self-assembly; (b) whole body fluorescence images of MCF7-tumor-bearing nude mice intravenously injected through a tail vein with FCNPs and free Ce6 (equivalent to 4.0 mg Ce6 per kilogram FCNs) at different times, black circles indicate tumor sites; (c) measured tumor size for 20 days growth (the number of mice in each group n=4)
    Fig. 1. (a) Fabrication of photosensitive nanoparticles by amphiphilic dipeptide- or amino-acid- tuned self-assembly; (b) whole body fluorescence images of MCF7-tumor-bearing nude mice intravenously injected through a tail vein with FCNPs and free Ce6 (equivalent to 4.0 mg Ce6 per kilogram FCNs) at different times, black circles indicate tumor sites; (c) measured tumor size for 20 days growth (the number of mice in each group n=4)
    Schematic of ALA pseudopolyrotaxane prodrug micelles for photodynamic therapy
    Fig. 2. Schematic of ALA pseudopolyrotaxane prodrug micelles for photodynamic therapy
    (a) Synthesis of the disulfide rebridging and bioconjugation reagent 6 (azide double sulfone); (b) functionalization of SST to receive Ru-SST conjugate 8 (Ru-SST8)
    Fig. 3. (a) Synthesis of the disulfide rebridging and bioconjugation reagent 6 (azide double sulfone); (b) functionalization of SST to receive Ru-SST conjugate 8 (Ru-SST8)
    A concept of enzyme activatable fluorescence imaging and photodynamic therapy using a photosensitizer-conjugated gold nanorod (MMP2P-GNR)
    Fig. 4. A concept of enzyme activatable fluorescence imaging and photodynamic therapy using a photosensitizer-conjugated gold nanorod (MMP2P-GNR)
    Simplified representation of a stepwise assembly process of final APMECR@MB NCs and the synergistic PDT/PTT mechanism of their action
    Fig. 5. Simplified representation of a stepwise assembly process of final APMECR@MB NCs and the synergistic PDT/PTT mechanism of their action
    Schematic of TMB. (a) FRET mode of TMB in the closed and opened forms; (b) hairpin DNA sequence and the separation distance of each FRET pair
    Fig. 6. Schematic of TMB. (a) FRET mode of TMB in the closed and opened forms; (b) hairpin DNA sequence and the separation distance of each FRET pair
    A schematic of activatable nano-photo medicine for macrophage-targeted fluorescence imaging and subsequent photodynamic therapy
    Fig. 7. A schematic of activatable nano-photo medicine for macrophage-targeted fluorescence imaging and subsequent photodynamic therapy
    Schematic illustration of the preparation of Ce6-CPT-UCNPs and concept of the light-regulated ROS-activated Ce6-CPT-UCNPs
    Fig. 8. Schematic illustration of the preparation of Ce6-CPT-UCNPs and concept of the light-regulated ROS-activated Ce6-CPT-UCNPs
    Schematic of the preparation and functional principle of AQ4N-Cu(II)-Apt Ce6-GNPs
    Fig. 9. Schematic of the preparation and functional principle of AQ4N-Cu(II)-Apt Ce6-GNPs
    Lan Shanyou, Zhang Da, Liu Xiaolong, Zeng Yongyi. Tumor-Microenvironment Activable Smart Nanocarrier System for Photodynamic Therapy of Cancers[J]. Chinese Journal of Lasers, 2018, 45(2): 207008
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