Author Affiliations
Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine, PLA Academy of Military Sciences, Beijing 100071, Chinashow less
Fig. 1. SERS nanomaterials in various dimensions and their applications
[30] Fig. 2. TEM images and UV-vis spectra of 0D SERS nanomaterials applied in SERS-ICA. (a) Gold nanostars
[32]; (b) Au@Ag nanoparticles
[33]; (c) Ag@ SiO
2 nanoparticles
[34]; (d) Fe
3O
4@Au MNPs
[23] Fig. 3. Characterization of 1D SERS nanomaterials applied in SERS-ICA. (a) TEM image of Au NPs
[36]; (b) UV-vis spectra and (c) Raman spectra of Au NRs with different aspect ratios
[36]; (d) TEM image and (e) normalized extinction spectra of GERTs
[37]; (f) SEM image of CNTs/AgNPs
[38] Fig. 4. Characterization of 2D SERS nanomaterials applied in SERS-ICA. (a) TEM image and (b) EDX spectrum of TiC/Au-NPs
[40]; (c) TEM image and (d) UV-vis spectra of GO@Au nanosheets
[41]; (e) TEM of MXene/MoS
2@Au NPs
[42] Fig. 5. Characterization of 3D SERS nanomaterials applied in SERS-ICA. (a) TEM image, (b) elemental mapping image, and (c) simulation model of GO@Au/Ag
[44]; (d) TEM image and (e) Raman spectra of GO@Au/Au nanosheets
[45]; (f) TEM iamge of 3D-MoS
2 nanoflowers
[46] Fig. 6. Schematic of SERS-ICA for the detection of IL-6 and PCT
[47]. (a) Preparation of SERS tags and assemblely of strips; (b) detection principle of SERS-ICA in the presence and absent of IL-6 and PCT
Fig. 7. Schematic of SERS-ICA for bacteria detection. (a) Detection of
Escherichia coliO157∶H7 via SERS probe based on hierarchical flowerlike Au NPs
[48]; (b) detection of
Yersinia pestis,
Francisella tularensis, and
Bacillus anthracis via SERS probe based on colloidal Au NPs
[49]; (c) detection of
Escherichia coliO157∶H7
via SERS probe based on SiO
2@Au NPs
[50]; (d) detection of
Staphylococcus aureus,
Escherichia coliO157∶H7, and
Salmonella typhimurium via SERS probe based on GO@Au nanosheets
[41] Fig. 8. Schematic of SERS-ICA for virus detection. (a) Dual-mode SERS-ICA for simultaneous detection of H1N1 and SARS-CoV-2 virus
[53]; (b) detection of H1N1 virus and adenoviruses via magnetic SERS tags based on Fe
3O
4@Ag
[54]; (c) detection of fumonisin B1, aflatoxin B1, and zearalenone via 3D nanosheets tags based on GO@Au
[45]; (d) detection of six mycotoxins via multiplex SERS-ICA strips
[55] Fig. 9. Schematic of SERS-ICA for the detection of nucleic acids. (a) SERS-ICA for the detection of HIV-1 based on MGITC-Au NPs
[58]; (b) SERS-based lateral flow microarray for the detection of respiratory tract infections
[59]; (c) CRISPR-Cas12a-based SERS-ICA for the detection of HIV-1
[61] Fig. 10. Schematic of SERS-ICA for protein detection. (a) Simultaneous analysis of anti-SARS-CoV-2 IgM/IgG via the SERS-ICA based on SiO
2@Ag
[63]; (b) detection of cancer marker antigens via portable SERS-ICA reader based on multichannel ICA reaction column
[65]