Qingming Lü, Binbin Luo, Qi Yang, Yang Zhang, Shengxi Wu, Zhipeng Gu, Shenghui Shi, Decao Wu, Taojiang Wu, Mingfu Zhao. Immunodetection of Alpha-Fetoprotein Based on Dual-Channel Probe Type 81° Tilted Fiber Grating[J]. Acta Optica Sinica, 2021, 41(7): 0706004
- Acta Optica Sinica
- Vol. 41, Issue 7, 0706004 (2021)
Fig. 1. Polarization correlation spectrum of the TFG. (a) Optical path coupling principle of probe type 81°TFG; (b) transmission type 81°TFG; (c) probe type 81°TFG
Fig. 2. Schematic diagram of the experimental system
Fig. 3. RI sensitivity calibration of the dual-channel probe type 81°TFG sensor. (a) Probe type 81°TFG1; (b) probe type 81°TFG2
Fig. 4. Surface modification and biofunctionalization process of the probe type 81°TFG-LSPR
Fig. 5. RI sensitivity of probe type 81°TFG before and after modification
Fig. 6. FESEM images of the probe type 81°TFG. (a) Modified with AuNs; (b) modified with AuNs and GO
Fig. 7. Energy spectrum of the probe type 81°TFG surface modified with AuNs and GO
Fig. 8. AFP antigen detection control experiment of dual-channel sensor. (a) Change curve of the spectrum with mass concentration; (b) change curve of the resonance wavelength shift with time
Fig. 9. Change curve of resonant wave long red shift with anti-primary solution quality concentration
Fig. 10. Clinical experiment spectrum and resonance wavelength changes of dual-channel biosensor. (a) Change curve of the spectrum; (b) change curve of the wavelength
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Table 1. Elemental mass fractions of AuNs and GO after surface modification of probe type 81°TFGunit: %
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