The ground validation of radiometric calibration results of optical sensors is comprehensive affected by many uncertainty factors in earth-atmosphere system, which leads to the difference of single verification results in single site, and unable to effectively compare and comprehensively analyze the results. In this study, in consideration of the influence of target characteristics, atmospheric environment, and other factors on the single verification results of single site, a comprehensive weighting method based on weighted average value with the uncertainty of verification results as the weight is proposed to obtain the key comparative reference value (KCRV) closer to the real value, so as to realize the comparison and comprehensive analysis of single site verification results. Meanwhile, the radiometric calibration results of ZY-3/MUX made in China are comprehensively verified based on the ground targets with different reflection characteristics in the national high resolution remote sensing integrated calibration field. The results show that the KCRVs of 12 validation samples in blue, green, red and near-infrared bands are 3.88%、5.42%、6.14%、9.81% respectively, the corresponding uncertainty is 1.79%, 1.87%, 1.96%, and 2.02%, respectively. Among them, the equivalence degrees of 9 validation samples are less than 0.1, prove that the validation results of these samples are closer to KCRV.