In order to further study the hardness and wear resistance of laser cladding Ni-Al/Al2O3-13%TiO2 cermet coating, a YLS-2000 fiber laser was used to prepare Ni-Al coating and Ni-Al/Al2O3-13%TiO2 cermet coating on a 45 steel substrate .The metallographic microscope, scanning electron microscope, electronic differential system energy spectrum analysis, X-ray diffraction and other systems were used to study the microstructure, phase composition, and element distribution of the coating. HXD-1000TB Vickers hardness tester was used to measure the micro-hardness distribution of the coating section, and the wear test was performed by using the M-2000 abrasion tester. The Ni-Al / Al2O3-13%TiO2 cermet coating has good macro-forming quality and no cracks. The maximum cross-section hardness of the coating is about twice that of the Ni-Al coating and about four times that of the substrate. Its wear volume is about 1/8 of that of the 45 steel substrate, which is 30% lower than that of Ni-Al coating. The structure of Ni-Al/Al2O3-13%TiO2 cermet coating is more uniform and dense, and its hardness and wear resistance are significantly improved compared to Ni-Al coating and matrix material. This research has certain reference significance for the overall performance analysis of cermet materials.