In order to obtain optimal process parameters of the laser cladding Ni35WC11 coating, a single factor control method is adopted. Three process parameters, including laser power, powder feeding rate and scanning speed, are used as control variables. The dilution ratio, height and width of the cladding layer are used as reference indexes for orthogonal range analysis. The results show that the influences of powder feeding rate, scanning speed and laser power on the reference indexes decrease gradually. The optimal parameters obtained by single factor and orthogonal analysis are laser power of 1500 W , powder feeding rate of 2 g/s and scanning speed of 4 mm/s. Samples are prepared according to these parameters. The hardness of the as-prepared cladding layer is about 710 HV, the self-corrosion potential is -0.72 V, and the self-corrosion current density is 0.96 A/cm ², indicating the cladding layer obtained under optimal parameters has high hardness, uniform structure, and strong corrosion resistance.