The photoelectric seeker is an important part of intelligent ammunition, and information processing is the core key technology of its precision guidance. From the perspective of engineering application, the main tasks and technical requirements of the information processing of the photoelectric seeker were systematically analyzed, and the classic distributed modular information processing design technical schemes were sorted out, and its significant advantages and main disadvantages were summarized. With the changes in the requirements of precision guided weapons in future combat objectives, environments and missions, in order to adapt to the development trend of multi-mode composite, intelligent, miniaturized, lightweight and low-cost photoelectric seekers, better meet the constraints of the missile environment urgent needs, make full use of the innovative results of VLSI and information processing technology, in the overall architecture of the photoelectric seeker system, the design ideas of integrated and miniaturized information processing were put forward, and typical application schemes was got, and the core performance was designed. It has significant advantages in terms of comprehensive cost and power consumption, and has strong versatility, which is conducive to the integration of missile guidance platform architecture, missile serialization and upgrading, and provides a reference for the development of a new generation of advanced photoelectric seeker engineering.