Waterfront resources in the middle reaches of the Yangtze River are abundant, with quite high value of development and utilization. This paper establishes, based on sufficient analysis on characteristics of waterfront resources and geological environmental conditions in the middle reaches of the Yangtze River, the evaluation model for construction appropriateness of major projects such as port and wharf, river-crossing bridge and river-crossing tunnel etc. in the perspective of geology; classifies various project types into four levels i.e. appropriate for development, relatively appropriate for development, generally appropriate for development, and non-priority development by analytic hierarchy process (AHP) and conducts zoning evaluation. According to the results, the port terminal in the middle reaches of the Yangtze River is dominated by non-priority development areas, with a length of 931.47 km, accounting for 46.71% of the total length of the coastline; cross-river tunnels and cross-river bridges are mainly suitable for development and generally suitable for development areas, with the lengths being 1550.75 km and 1224.18 km, respectively, or 77.77% and 61.39% of the total length of the coastline. Finally, we put forward suggestions and rectification measures according to characteristics of each project level, so as to privide a theoretical basis for construction and deployment of major projects in terms of geology, promote the scientifically reasonable development and utilization as well as the effective protection of waterfront resources in the middle reaches of the Yangtze River, and further facilitate the development of Yangtze River Economic Zone and national spatial planning, and protect the sustainable and sound development of Yangtze River.