• Acta Photonica Sinica
  • Vol. 51, Issue 7, 0751408 (2022)
An PAN1、2、*, Yuting GAO1、2, Aiye WANG1、2, Huiqin GAO1、2, Caiwen MA1、2, and Baoli YAO1、2
Author Affiliations
  • 1Xi'an Institute of Optics and Precision Mechanics,Chinese Academy of Sciences,Xi'an 710119,China
  • 2University of Chinese Academy of Sciences,Beijing 100094,China
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    DOI: 10.3788/gzxb20225107.0751408 Cite this Article
    An PAN, Yuting GAO, Aiye WANG, Huiqin GAO, Caiwen MA, Baoli YAO. High-throughput Full-color Fourier Ptychographic Microscopy for the Next Generation of Digital Pathologic Imager and Analyser(Invited)[J]. Acta Photonica Sinica, 2022, 51(7): 0751408 Copy Citation Text show less
    The intrinsic drawbacks of conventional digital pathologic scanners
    Fig. 1. The intrinsic drawbacks of conventional digital pathologic scanners
    The trend of FPM on several aspects
    Fig. 2. The trend of FPM on several aspects
    The comparisons between ptychography[102],FPM[127],and Structured Illumination Microscopy(SIM)
    Fig. 3. The comparisons between ptychography102,FPM127,and Structured Illumination Microscopy(SIM)
    The flowchart of FPM reconstruction algorithm
    Fig. 4. The flowchart of FPM reconstruction algorithm
    Roadmap on FPM in digital pathology[3,33,43,57,76,105]
    Fig. 5. Roadmap on FPM in digital pathology333435776105
    Several typical FPM results[3,43,56,106]
    Fig. 6. Several typical FPM results34356106
    Multimodal imaging[101,158]
    Fig. 7. Multimodal imaging101158
    The potential requirements in the whole workflow of digital pathology to accelerate the output of reports[62,76,109,167-168,172]
    Fig. 8. The potential requirements in the whole workflow of digital pathology to accelerate the output of reports6276109167-168172
    Comparisons of the throughput of existing commercial products
    Fig. 9. Comparisons of the throughput of existing commercial products
    DepartmentsChecklistRequired timeType of diagnosis
    Clinical laboratoryBiochemistry & ImmunityHepatic and renal function2 hoursDeductive Diagnosis
    Blood glucose,lipids,electrolytes
    Routine immunization
    LuminescenceTumor markersOn that day
    Thyroid function
    Gonadal hormone
    BacteriaSmear and stainingOn that day
    Bacterial culture4 hours
    Picture archivingX-ray1 hours
    Ultrasound
    Magnetic Resonance Imaging(MRI)
    PathologyConventional small sample3 daysDefinitive Diagnosis
    Large samples of surgical removal5 days
    Immunohistochemistry,molecular pathology7~10 days
    Table 1. The information of checklist and its required time at a typical hospital in China
    An PAN, Yuting GAO, Aiye WANG, Huiqin GAO, Caiwen MA, Baoli YAO. High-throughput Full-color Fourier Ptychographic Microscopy for the Next Generation of Digital Pathologic Imager and Analyser(Invited)[J]. Acta Photonica Sinica, 2022, 51(7): 0751408
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