In allusion to the difficult-to-remove oxide layers on a titanium rolled plate surface, a process for laser cleaning the oxide layer on a titanium rolled plate surface is investigated using a laser cleaning machine with an average power of 200 W. Based on the law of the temperature rise of the metal oxide under the action of the laser, raising the laser single-pulse power density is proposed as an effective solution to the problem of laser removal of the oxide layers. Combined with the results of energy-dispersive X-ray spectroscopic analysis and the cleaning effect of the oxides on the surface of titanium rolled plate under different laser cleaning processes, the oxide on the surface of the titanium rolled plate is shown to be effectively removed using laser cleaning when the laser power density reaches 4×10 ⁸ W/cm ². Noticeably, this process does not affect the tensile properties of the material.