Trying to provide a more effective algorithm for real-time counterpoint and alignment in the image, we propose an estimate method using affine transformation modal to calculate image translation rotation parameters, which is different from the traditional iteration method in searching image. It’s the first time to provide the algorithm which can calculate target and alignment image registration parameter by single step, using the model of the least square of the affine transformation homography. And the effectiveness of this algorithm is validated through the corresponding experiment.