Selective laser melting (SLM) technology is used to fabricate the CoCrMo alloy standard specimen. With the casted CoCrMo alloy and SLM manufactured CoCrMo alloy respectively combined with the ultrahigh molecular weight polyethylene (UHMWPE), the wear-resistance experiment is conducted. The experiments show that, under the four kind of lubrication conditions including dry friction, physiological saline, artificial saliva, and calf serum, the friction coefficient of the SLM manufactured CoCrMo alloy is always less than that of casted CoCrMo alloy. In addition, under different lubrication conditions, the wear mechanisms of the SLM manufactured CoCrMo/UHMWPE and the casted CoCrMo/UHMWPE are different.