A phase unwrapping algorithm is proposed based on the coefficient solution of wavefront aberration mode. The algorithm is implemented on the basis that wavefront can be accurately represented by Zernike polynomials. By solving the coefficients of the corresponding Zernike polynomials, we realized a fast and accurate phase unwrapping. Taking the phase unwrapping in the wavefront sensing based on binary aberration mode measurement as the research target, we verify the feasibility of the algorithm by numerical simulation. Numerical simulation results show that compared with the least square phase unwrapping algorithm, the proposed phase unwrapping algorithm realizes a great improvement in accuracy and speed of unwrapping.