The coherent control of multi-dressed four-wave mixing (FWM) Autler-Townes (AT) splitting is mainly investigated. It is shown that the transformation of the FWM signals from singly-dressing to cascade doubly-dressing is realized by controlling the quantity of the additional dressing fields. Moreover, the AT splitting phenomena of the singly-dressed or doubly-dressed FWM signals can be observed when the frequency detuning of probe field is scanned. The second-order AT splitting phenomena of the doubly-dressed FWM signal is also observed. The factors influencing the position and linewidth of AT splitting are finally analyzed. The research results show that the position and linewidth of AT splitting can be coherently controlled by Rabi frequency or frequency detuning of the dressing field.