By use of the laser-welding technique, the tailor-welded joints of DP980 and 22MnB5 are fabricated, and their microstructures and properties are researched. The results show that an obvious softening occurs in the heat-affected zone (HAZ) of DP980 and the minimum hardness of the softening zone is about 75% of that of the DP980 base material, however, there is no softening phenomenon in the HAZ of 22MnB5 where the hardness is increased to 2-2.4 times that of 22MnB5 base material. The tailor-welded joints have fractures at the 22MnB5 base material, whose tensile strength is around 670 MPa. The softening zone of the HAZ of DP980 is composed of temper martensite and ferrite, the two-phase zone is of a small amount of quenched martensite and ferrite, and the hardening zone is basically of lath martensite. The incomplete quenching zone of the HAZ of 22MnB5 has a similar composition with the two-phase zone of DP980 side, the complete quenching zone is of all lath martensite, and the weld zone is of coarse lath martensite.