Continuous Terahertz Wave Biological Tissue Imaging Technology Based on Focal Plane Array

Yuye Wang; Bozhou Jiang; Degang Xu; Guoqiang Wang; Yifan Wang; Jianquan Yao

doi:10.3788/AOS202141.0711001

[1] Markelz A G, Roitberg A, Heilweil E J. Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz[J]. Chemical Physics Letters, 320, 42-48(2000).

[2] Jepsen P U, Cooke D G, Koch M. Terahertz spectroscopy and imaging-modern techniques and applications[J]. Laser & Photonics Reviews, 5, 124-166(2011).

[3] Kawabe S, Seki M, Tabata H. Evaluation of hydration in a water-soluble polymer by terahertz spectroscopy[J]. Applied Physics Letters, 108, 081103(2016).

[4] Hu B B, Nuss M C. Imaging with terahertz waves[J]. Optics Letters, 20, 1716-1718(1995).

[5] Davies A G, Burnett A D, Fan W H et al. Terahertz spectroscopy of explosives and drugs[J]. Materials Today, 11, 18-26(2008).

[6] Hoshina H, Sasaki Y, Hayashi A et al. Noninvasive mail inspection system with terahertz radiation[J]. Applied Spectroscopy, 63, 81-86(2009).

[7] Fukunaga K, Hosako I. Innovative non-invasive analysis techniques for cultural heritage using terahertz technology[J]. Comptes Rendus Physique, 11, 519-526(2010).

[8] Wang Y Y, Wang L P, Li T et al. Terahertz characteristic absorption spectrometric analysis of homocysteine[J]. Acta Optica Sinica, 39, 1030003(2019).

[9] Sun Q, He Y, Liu K et al. Recent advances in terahertz technology for biomedical applications[J]. Quantitative Imaging in Medicine and Surgery, 7, 345-355(2017).

[10] Fu Z L, Li R Z, Li H Y et al. Progress in biomedical imaging based on terahertz quantum cascade lasers[J]. Chinese Journal of Lasers, 47, 0207014(2020).

[11] Wang Y Y, Chen L Y, Xu D G et al. Three-dimensional reconstruction of rat brain trauma based on terahertz imaging[J]. Acta Optica Sinica, 39, 0317002(2019).

[12] Lee A W, Hu Q. Real-time, continuous-wave terahertz imaging by use of amicrobolometer focal-plane array[J]. Optics Letters, 30, 2563-2565(2005).

[13] Yang J, Ruan S C, Zhang M. Real-time, continuous-wave terahertz imaging by a pyroelectric camera[J]. Chinese Optics Letters, 6, 29-31(2008).

[14] Li Q, Yao R, Shan J X et al. A preliminary study on THz imaging and image enhancement based on thermal imager[J]. Acta Optica Sinica, 28, 275-277(2008).

[15] Oda N, Ishi T, Morimoto T et al. Real-time transmission-type terahertz microscope with palm size terahertz camera and compact quantum cascade laser[J]. Proceedings of SPIE, 8496, 84960Q(2012).

[16] Simoens F, Meilhan J. Terahertz real-time imaging uncooled array based on antenna- and cavity-coupled bolometers[J]. Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences, 372, 20130111(2014).

[17] Oda N, Kurashina S, Miyoshi M et al. Microbolometer terahertz focal plane array and camera with improved sensitivity in the sub-terahertz region[J]. Journal of Infrared, Millimeter, and Terahertz Waves, 36, 947-960(2015).

[18] Rong L, Latychevskaia T, Chen C et al. Terahertz in-line digital holography of human hepatocellular carcinoma tissue[J]. Scientific Reports, 5, 8445(2015). http://europepmc.org/abstract/med/25676705

[19] Guo L, Wang X, Han P et al. Observation of dehydration dynamics in biological tissues with terahertz digital holography[J]. Applied Optics, 56, F173-F178(2017). http://europepmc.org/abstract/MED/28463312

[20] Zhang X L, Du G H, Deng B et al. High precision measurement of modulation transfer function for X-ray CCD with knife-edge method[J]. Acta Optica Sinica, 30, 1680-1687(2010).

[21] Qi L, Zhao M C, Zhao J et al. Characteristic difference of porcine tissues by terahertz attenuated total reflectance spectroscopy[J]. Food & Machinery, 34, 11-14, 61(2018).

[22] Wu L M, Xu D G, Wang Y Y et al. Study of in vivo brain glioma in a mouse model using continuous-wave terahertz reflection imaging[J]. Biomedical Optics Express, 10, 3953-3962(2019).

[23] Oh S J, Kim S H, Ji Y B et al. Study of freshly excised brain tissues using terahertz imaging[J]. Biomedical Optics Express, 5, 2837-2842(2014).

[24] Cao Q. A study of spatial filtering and image processing in measuring system with laser beam irradiation[D]. Wuhan: Huazhong University of Science and Technology, 15-18(2005).