The TiC+TiB2 reinforced Ni-based self-lubricant composite coatings are prepared on the TC4 matrix surface by the laser cladding technique, and the effect of CeO2 content on the phase compositions, microstructures, microhardness and friction and wear performances of these coatings is investigated. The results show that the phase compositions of these coatings with different CeO2 contents are mainly composed of matrix γ-Ni, ceramic-reinforced phases of TiC and TiB2, intermetallic compound of Ti2 Ni, and lubricant phase of Ti3SiC2. The addition of suitable content of CeO2 can make the reinforced phase size decreased and grains refined. When the CeO2 content is 1.5%, the microhardness is around 1400 HV, the lowest friction coefficient is between 0.22 and 0.24, and the lowest wear mass loss is 1.7 mg, which indicate that these coatings possess nice self-lubricant and wear-resistant performances.