Fig. 1. Registration flow chart of narrow-band light blood vessel image in V-PDT

Fig. 2. MSD line graph of different registration groups in V-PDT for three ICR mice

Fig. 3. Comparison of pseudo-color fusion images and difference images of slight and severe deformation for ICR mouse T3. (a1)(a2) Pseudo-color fusion image and difference image of 8th registration group; (b1)(b2) pseudo-color fusion image and difference image of 9th registration group

Fig. 4. MSD, DC line graphs after registration of different registration groups and registration time histograms of 12 registration groups for three ICR mice during V-PDT treatment. (a1) (b1) (c1) MSD line chart; (a2) (b2) (c2) DC line chart; (a3) (b3) (c3) histogram of registration time for each algorithm

Fig. 5. Difference images for 7th and 9th registration groups after registration using different algorithms for ICR mouse T3.(a1)(b1) Unregistered; (a2)(b2) SURF-TPS; (a3)(b3) Log-Demons; (a4)(b4) SURF-TPS+Log-Demons; (a5)(b5) proposed algorithm

Fig. 6. Pseudo-color fusion images of 6th, 8th and 9th registration group for ICR mice T1, T2 and T3 respectively, and Time-dependent changes of vascular area contraction rate in the red box area before and after registration. (a1)(b1)(c1) Pseudo-color fusion images of 6th, 8th and 9th registration groups for ICR mice T1,T2 and T3; (a2)(b2)(c2) time-dependent changes of vascular area contraction rate in the red box area before and after registration