Author Affiliations
11. School of Materials Science and Engineering, Tongji University, Shanghai 201804, China22. Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Institute of Rehabilitation Medicine, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, Chinashow less
1. Characterization of MBGC-xNd microspheres(a-e) TEM images of (a) MBN, (b) MBGC-0Nd microspheres, (c) MBGC-1Nd microspheres, (d) MBGC-3Nd microspheres, and (e) MBGC-5Nd microspheres; (f) High-resolution TEM image of MBGC-3Nd microspheres with insert showing the interplanar crystal spacing at about 0.334 nm; (g) XRD patterns of MBN and MBGC-xNd microspheres; (h) N2 adsorption-desorption isotherm and (i) pore size distribution curve of MBGC-xNd microsphere The color figures can be obtained from online edition
Scheme 1. Schematic diagram of preparation and properties of MBGC-xNd microspheres and MBGC-xNd/SA bone cementThe color figure can be obtained from online edition
2. Changes of (A) Ca and (B) Si concentrations with MBGC-xNd microspheres in SBFThe color figures can be obtained from online edition
3. Cumulative release curves of DOX from (A) MBGC-xNd@DOX microspheres in PBS at pH 4.7 and (B) MBGC-3Nd/SA@DOX in PBS at pH 4.7 under different ambient temperaturesThe color figures can be obtained from online edition
4. Photothermal properties of MBGC-xNd microspheres(A) Heating curves of MBGC-xNd microspheres under 808 nm laser irradiation (3.2 W/cm2); (B) Heating curves of MBGC-3Nd microspheres under 808 nm laser irradiation at different power densities; (C) Heating curves of MBGC-3Nd/SA immersed in SBF under 808 nm laser irradiation (2.4 W/cm2); (D) Energy level diagram of Nd3+The color figures can be obtained from online edition
5. Characterization of MBGC-3Nd/SA bone cement(A) Photo of extruded bone cement; (B) SEM image of MBGC-3Nd/SA; (C) Schematic illustration of the setting process of MBGC-3Nd/SAThe color figures can be obtained from online edition
6. Setting properties of MBGC-xNd/SA(A) Setting time; (B) Injectability; (C) Compressive strength; (D) Anti-washout property. *: p<0.05 (n=5)The color figures can be obtained from online edition
7. (A) Proliferation results and (B) alkaline phosphate activity of rBMSCs cultured in the bone cement extract*: p < 0.05; **: p < 0.01. (n = 5).The color figure can be obtained from online edition
8. Relative survival of MG-63 cells co-cultured with (A) bone cement under 808 nm laser irradiation at a power density of 2.4 W/cm2 for 5 min and (B) MBGC-3Nd/SA under PTT, CHT or combination therapy.*: p<0.05; **: p<0.01, ***: p<0.001 (n=5)The color figures can be obtained from online edition
Sample | SiO2 | B2O3 | P2O5 | CaO | NdO3/2 |
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MBGC-0Nd | 50 | 10 | 4 | 36 | 0 | MBGC-1Nd | 50 | 10 | 4 | 35 | 1 | MBGC-3Nd | 50 | 10 | 4 | 33 | 3 | MBGC-5Nd | 50 | 10 | 4 | 31 | 5 |
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Table 1. Composition in molar percent of MBGC-xNd microspheres
Sample | Specific surface area/(m2·g-1)
| Pore size /nm | Pore volume /(cm3·g-1)
|
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MBN | 329.261 | 12.506 | 0.4498 | MBGC-0Nd | 42.092 | 6.024 | 0.0634 | MBGC-1Nd | 36.065 | 4.776 | 0.0431 | MBGC-3Nd | 34.424 | 4.496 | 0.0387 | MBGC-5Nd | 28.818 | 3.710 | 0.0268 |
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Table 2. Pore structure of MBN and MBGC-xNd microspheres