Under different process parameters, the laser cladding of Ni-based alloys on the spheroidal graphite cast iron QT450-10 surface is conducted, the microstructure and the phase compositions of cladding layers are analyzed, and the tensile stress-strain curves of samples with and without laser cladding and the fracture morphologies of samples are studied. The results show that, when the laser power is 1.6 kW, the laser scanning speed is 400 mm·min-1 and the powder feeding speed is 3.2 r·min-1, better quality cladding layer can be achieved and a good metallurgical bonding is formed between the matrix and the cladding layer where no cracks and pores are observed. Under the temperature of 25 ℃ and when the cladding layer number is 1, the microhardness of cladding layers is 265 HV, about 1.5 times of that of the matrix. The fracture site of cladding samples is in the matrix. After the laser cladding of Ni-based alloys, the strength of the spheroidal graphite cast iron is enhanced.