Intracranial hypertension is a serious threat to the health of neurosurgical patients. At present, there is a lack of a safe and effective technology to monitor intracranial pressure (ICP) accurately and nondestructively. In this paper, based on near infrared technology, the continuous nondestructive monitoring of ICP change caused by brain edema was studied. The rat brain edema models were constructed by lipopolysaccharide. The ICP monitor and the self-made near infrared tissue parameter measuring instrument were used to monitor the invasive intracranial pressure and the reduced scattering coe±cient of brain tissue during the brain edema development. The results showed that there was a negative correlation between the reduced scattering coe±cient (690nm and 834nm) and ICP, and then the mathematical model was established. The experimental results promoted the development of nondestructive ICP monitoring based on near infrared technology.