• Journal of Inorganic Materials
  • Vol. 36, Issue 10, 1091 (2021)
Keke SONG1, Hao HUANG2, Mengjie LU3, Anchun YANG2, Jie WENG1、2、*, and Ke DUAN4、*
Author Affiliations
  • 11. College of Medicine, Southwest Jiaotong University, Chengdu 610031, China
  • 22. Key Lab on Advanced Technologies of Materials (MOE), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
  • 33. Pathology department, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
  • 44. Sichuan Provincial Lab of Orthopaedic Engineering, Department of Orthopaedics, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
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    DOI: 10.15541/jim20200664 Cite this Article
    Keke SONG, Hao HUANG, Mengjie LU, Anchun YANG, Jie WENG, Ke DUAN. Hydrothermal Preparation and Characterization of Zn, Si, Mg, Fe Doped Hydroxyapatite[J]. Journal of Inorganic Materials, 2021, 36(10): 1091 Copy Citation Text show less

    Abstract

    Doping of trace elements is an effective way to endow hydroxyapatite with more biological functions. But the behaviors of different element doping remained to be further revealed. Here, nine kinds of hydroxyapatite particles containing zinc, silicon, magnesium, iron, manganese, copper, strontium, selenium, and cobalt, respectively, were prepared by parallel hydrothermal synthesis, and their physicochemical properties were studied. The results show that the morphology and crystal growth direction of hydroxyapatite particles are significantly changed, while the phase composition is maintained. The peak intensity of (211) and (112) plane diffraction peaks decreased, accompanied by decreased crystallinity. Analysis results show that the actual doping efficiency obeys the tendency of manganese > zinc > magnesium > iron (trivalent) > strontium > cobalt > copper > selenium > silicon. Among these elements, doping amounts of Mn, Zn and Mg are higher, because their ion radii are closed to that of Ca 2+. The low doping efficiency of copper is caused by its complexation with ammonia in synthetic solution, while silicon and selenium are caused by different geometry and charge of SiO32-, SeO32- from that of PO43-. This study reveals the reasonable relationship between doping behavior and ion characteristics, providing a useful reference for design and development of functionalized hydroxyapatite.
    Keke SONG, Hao HUANG, Mengjie LU, Anchun YANG, Jie WENG, Ke DUAN. Hydrothermal Preparation and Characterization of Zn, Si, Mg, Fe Doped Hydroxyapatite[J]. Journal of Inorganic Materials, 2021, 36(10): 1091
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