• Journal of Inorganic Materials
  • Vol. 36, Issue 10, 1091 (2021)
SONG Keke1, HUANG Hao2, LU Mengjie3, YANG Anchun2, WENG Jie1、2、*, and DUAN Ke4、*
Author Affiliations
  • 11. College of Medicine, Southwest Jiaotong University, Chengdu 610031, China
  • 22. Key Lab on Advanced Technologies of Materials (MOE), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
  • 33. Pathology department, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
  • 44. Sichuan Provincial Lab of Orthopaedic Engineering, Department of Orthopaedics, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
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    Doping of trace elements is an effective way to endow hydroxyapatite with more biological functions. But the behaviors of different element doping remained to be further revealed. Here, nine kinds of hydroxyapatite particles containing zinc, silicon, magnesium, iron, manganese, copper, strontium, selenium, and cobalt, respectively, were prepared by parallel hydrothermal synthesis, and their physicochemical properties were studied. The results show that the morphology and crystal growth direction of hydroxyapatite particles are significantly changed, while the phase composition is maintained. The peak intensity of (211) and (112) plane diffraction peaks decreased, accompanied by decreased crystallinity. Analysis results show that the actual doping efficiency obeys the tendency of manganese > zinc > magnesium > iron (trivalent) > strontium > cobalt > copper > selenium > silicon. Among these elements, doping amounts of Mn, Zn and Mg are higher, because their ion radii are closed to that of Ca 2+. The low doping efficiency of copper is caused by its complexation with ammonia in synthetic solution, while silicon and selenium are caused by different geometry and charge of SiO32-, SeO32- from that of PO43-. This study reveals the reasonable relationship between doping behavior and ion characteristics, providing a useful reference for design and development of functionalized hydroxyapatite.

    羟基磷灰石(Ca10(PO4)6(OH)2, Hydroxyapatite, HA)是人体骨的主要无机成分, 临床上常用作骨骼创伤和缺损疾病的治疗[1]。除钙和磷之外, 人体骨矿物中含有的其他微量元素, 对骨骼发育起着重要作用[2,3,4]。其中, 铜(Cu)元素参与胶原的交联, 铜缺乏将降低骨骼力学性能[5,6]; 锌(Zn)是骨骼正常发育所必需的元素, 骨骼生长迟缓和骨质疏松症与锌缺乏有关[7,8]; 钴(Co)元素则可以以维生素B12和辅酶B12配合物的形式刺激造血功能, 影响骨生长[9]。此外, 铜、锌、钴元素均具有诱导血管生成和成骨细胞分化的能力, 可作为促进骨缺损愈合的补充剂[10,11,12]。硒(Se)是人体必需的微量元素, 可提高免疫系统的细胞增殖和抗体的合成水平, 从而提高机体免疫功能[13,14]。已有大量文献表明, 铁(Fe)、镁(Mg)、硅(Si)、锶(Sr)等其他微量元素对骨骼的发育和修复也有良好的促进作用[15,16,17,18,19,20]。因此研究合成元素离子掺杂HA可以模拟骨矿物的化学性质, 赋予合成HA更好的生物活性和特异治疗性能[21,22]。但前期研究只关注了一种或两种微量元素掺杂后HA的物相及生物学性能变化, 缺乏对这些元素掺杂特性的系统性研究。因此, 本研究将对微量元素的掺杂行为, 如进入HA晶格的趋势以及对HA晶体或粒子的物理化学特性影响等作深入探究。

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    Keke SONG, Hao HUANG, Mengjie LU, Anchun YANG, Jie WENG, Ke DUAN. Hydrothermal Preparation and Characterization of Zn, Si, Mg, Fe Doped Hydroxyapatite[J]. Journal of Inorganic Materials, 2021, 36(10): 1091
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    Received: Nov. 20, 2020
    Accepted: --
    Published Online: Nov. 26, 2021
    The Author Email: WENG Jie (jweng@swjtu.cn), DUAN Ke (keduan9@126.com)