Recently, many programs have been developed for simulation or analysis of the different parameters of light propagation in optical fibers, either for sensing or for communication purposes. In this paper, it is shown the COMSOL Multiphysics as a fairly robust and simple program, due to the existence of a graphical environment, to perform simulations with good accuracy. Results are compared with other simulation analysis, focusing on the surface plasmon resonance (SPR) phenomena for refractive index sensing in a D-type optical fiber, where the characteristics of the material layers, in terms of the type and thickness, and the residual fiber cladding thickness are optimized.