The laser fuze can realize omnidirectional detection of missile targets through the circumferential multi-channel layout, its active-rotational-narrow pulse detection method can obtain the information about missile-target distance, miss azimuth angle and target type. At the same time, due to the characteristics of narrow beam and no side lobes, the fuze initiation zone has a small distribution area. All of these factors provide an important technical approach for efficient fuze-warhead coordination. Based on the analysis of the influence factors of air-defense missile fuze-warhead coordination, a fuze-warhead system scheme with eight-channel circumferential laser fuze was designed, combined with missile-target distance, miss azimuth, and target type. The fuze-warhead coordination simulation results in conditions of typical encounter parameters indicate that, the kill probability of single missile could be obtained to a maximum of 10% with the laser fuze information. It is useful for optimal design.