With the comparison to traditional design method in opto-mechanical system,the basic frame of integrated analysis and simulation was conceived. A mirror in telescope was taken as an example,and Patran,Matlab/Simulink and Zemax were selected as the software environment,the each independent model was set up respectively,the realization methods for integrated analysis were discussed. On the basis of brief study on model generation and model reduction,the structural control interface tool was developed,and the structure control integrated analysis in mechanical/optical system was implemented. On the basis of study on dynamic data exchange (DDE),the method to the problem of a large number of ray tracing was discussed. The DDE of Matlab and Zemax and optical control integrated analysis in opto-mechanical system were implemented. The purpose of opto-mechanical control integrated analysis in opto-mechanical system was achieved.