In order to investigate cellular compatibility of hydroxyapatite(HA) target sintered at high temperature, the powder of 99% pure hydroxyapatite was pressed to discal targets and the targets were sintered at 800
C in argon ambience. The microstructure and composition of targets were detected with X-ray diffractometer(XRD) and X-ray photoelectron spectroscopy(XPS). The cellular compatibility of targets was detected with methyl thiazolyl tetrazolium(MTT). The experimental result demonstrates the chemical composition of targets was not changed while the powder of hydroxyapatite was pressed to targets and the targets were sintered at 800
C in argon ambience. The average particle diameter in target was 78.2 nm, the crystallinity in target was 89.4% and the ratio of Ca to P in target was 1.592. The hydroxyapatite target sintered at 800
C had cellular compatibility.