Taking Dzyaloshinskii-Moriya (DM) effect interaction into account, the entanglement of two-qubit Ising model in an inhomogeneous magnetic field is investigated by means of Negativity theory. It is shown that the existence of DM interaction can obviously enhance the entanglement and put it into a maximum while the magnetic field reduces the entanglement. In addition, low temperature also plays a positive role in entanglement. Moreover, the influence of inhomogeneous magnetic field is also investigated. These effects indicate that one can control the thermal entanglement by manipulation of DM interaction, the homogeneous and inhomogeneous magnetic field and temperature.