Author Affiliations
11. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China22. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, Chinashow less
1. Mechanism of anti-microbial infections of nanozymes
[25⇓⇓-28] 2. Antibacterial killing effect of a nanozyme, Q-MOF
Ce0.5[32](a, b) Plate count results of the antibacterial effects of Q-MOF
Ce0.5 on
E. coli (a) and
S. aureus (b); (c, d) Statistical results of the corresponding bacterial viability rates of
E. coli (c) and
S. aureus (d); (e) The live (SYTO-9, green)/dead (PI, red) staining results of
E. coli and
S. aureus; (f) Scanning electron microscope (SEM) results of bacterial samples treated by nanozymesColorful figures are available on website
3. Characterization and ROS generation ability of a nanozyme, Ag-TiO
2 SAN
[34](a, b) Transmission electron microscope (TEM) images of Ag-TiO
2 SAN co-localized with lysosomes of mouse (RAM 264.7) and human (THP-1) macrophages; (c, d) Ag-TiO
2 SAN enhanced ROS generation. THP-1: a kind of human monocytic leukemia cellColorful figures are available on website
4. Characterization, Ag
+ release, and ROS generation ability of Ag/BMO NPs through photodynamic combination therapy
[47](a) SEM image of Ag/BMO NPs; (b) Percentage release of Ag
+ at pH 7.35 and pH 6.75 showing photo-enhanced ROS generation ability of Ag/BMO; (c)
1O
2 detection result by probe of single oxygen sensor green; (d) ESR spectra of
1O
2; (e) ·OH detection result by MB indicator; (f) ESR spectra of ·OH. L: 1064 nm laser (1 W·cm
-2, 10 min) Colorful figures are available on website
5.
In vitro antimicrobial performance of Fe
3O
4-GOx based on cascaded reaction
[50](a) 2',7'-Dichlorofluorescein staining images of
E. coli and MRSA; (b) Growth curves of MRSA; (c) Representative SEM and live/dead staining images of MRSA; (d) Crystal violet staining image and its absorbance for integrated MRSA biofilmColorful figures are available on website
6.
S-Ab can be used as bio-orthogonal catalyst to complete shape-based selective recognition of bacteria and catalyze precursors into active antibacterial molecule
[56]Colorful figure is available on website
Mechanism | Nanozyme | Catalytic activity | Mechanism | Pathogens | Ref. |
---|
Generation ROS | Cu-MOF | OXD | ROS | E. coli; S. aureus | [25] | Cu-CD | POD | ROS | E. coli; S. aureus | [27] | Chitosan grafted Fe-doped-carbon dots (CS@Fe/CDs) | POD | ROS | P. aeruginosa; S. aureus. | [33] | Ag-TiO2 SAN | POD | ROS | SARS-CoV-2 | [34] | Fmoc-diphenylalanine hydrogel-eEncapsulated Pt | OXD; POD | ROS | E. coli; S. aureus | [57] | CFO@BFO nanozyme-eel | CAT | ROS | E. coli; MRSA | [58] | Cu2O@CuO; Cu@Cu2S nanodot | OXD; POD | ROS | E. coli; S. aureus | [59] | FeCo@PDA NPs | POD | ROS | E. coli; S. aureus | [60] | Fe3O4@SiO2@dendritic mesoporous silica@small-Fe3O4 nanoparticles | POD | ROS | E. coli | [61] | Mesoporous vanadium oxide nanospheres | POD | ROS | E. coli; S. aureus | [62] | Au3+-UiO-67 NMOFs | OXD; POD | ROS | E. coli; S. aureus | [63] | CS@Fe3O4 | POD; SOD; CAT | ROS | A. baumannii | [64] | N/Cl-CDs + Ag NPs | OXD | ROS | E. coli; S. aureus; MRSA | [65] | Cu-N-C | OXD; POD | ROS | E. coli; S. aureus; B. cereus; C. albicans; MRSA | [66] | PEGMA-co-GMA-co-AAm-HBPL-MnO2 hydrogel | CAT; POD | ROS | P. aeruginosa; S. aureus; E. coli | [67] | GOx-MOF hydrogel | GOx; POD | ROS | E. coli; S. aureus | [68] | Taurine-Cu-3(PO4)(2) hybrid nanoflower | POD | ROS | E. coli; S. aureus;B. cereus; C.albicans | [69] | FePO4-HG | POD; SOD; CAT | ROS | E. coli; S. aureus | [70] | Combination therapy | Au/MoO3-x | POD | Photothermal; ROS(O2•-) | MRSA | [26] | Cu-MOFN nanosheet | POD | Hot electron transferred ROS | S. aureus | [38] | CuSeNPs@MPBA | POD | Photothermal; ROS | E. coli; S. aureus | [43] | Hollow mesoporous Prussian blue nanoparticles (HMPBNPs) | POD | ROS; Photothermal | E. coli; S. aureus | [44] | Bacitracin-functionalized dextran-MoSe2(AMP/dex-MoSe2 NSs) | POD | Photothermal; ROS | E. coli | [45] | Mechanism | Nanozyme | Catalytic activity | Mechanism | Pathogens | Ref. | Combination therapy | Ag/Bi2MoO6 | POD | Photodynamic; ROS | S. aureus | [47] | CuxO-PDA | POD | Photothermal; ROS | E. coli; S. aureus | [48] | Histidine-containing carbon nanodots | OXD | Photodynamic; ROS | E. coli | [49] | VOx-artificial enzyme | OXD, POD | Electron enhanced ROS | S. aureus | [71] | EM@MoS2 | POD | Photothermal; ROS | S. aureus | [72] | LS-CuS@PVA | POD | Photothermal; Photodynamic; ROS | E. coli; S. aureus | [73] | D-A-conjugated COF | POD | Photothermal; Photodynamic; ROS | E. coli; S. aureus | [74] | Cu3SnS4 NSs | POD | Photothermal; ROS | E. coli; S. aureus | [75] | Mn3O4HNSs@ICG | OXD | Photothermal; Photodynamic; ROS | E. faecalis; E. coli; P. aeruginosa | [76] | Au NCs@PCN MOF | POD | Photothermal; ROS | E. coli; S. aureus | [77] | Ag (8.5%)@NiS2-x | POD | Photothermal; ROS | E. coli | [78] | Cascaded reaction | Fe3O4-GOx | GOx; CAT; POD | ROS | E. coli; S. aureus | [50] | Fe2(MoO4)3@GOx | GOx; POD | ROS | E. coli; S. aureus | [51] | ODex/gC/MoS2@Au@BSA Hydrogel | POD | ROS | E. coli; S. aureus | [79] | CuO nanospheres | POD; CAT | ROS | E. coli; S. aureus | [80] | MnFe2O4@MIL/Au&GOx(MMAG) | GOx; POD | ROS | E. coli; S. aureus | [81] | Bio-orthogonal catalysis | Man-NZs(Au, FeTPP) | | Bio-orthogonal catalysis | Salmonella; Lactobacillus sp. | [54] | Man-NZ | | Bio-orthogonal catalysis | E. coli; MSRA | [55] | E-Ab and S-Ab | | Bio-orthogonal catalysis | E. coli; S. aureus | [56] | Others | CeO2@ZrO2 | Haloperoxidase | HBr- | E. coli; S. aureus | [82] |
|
Table 1. Nanozymes for anti-microbial infections